TY - JOUR
T1 - Effects of an exercise program in colon cancer patients undergoing chemotherapy
AU - Van Vulpen, Jonna K.
AU - Velthuis, Miranda J.
AU - Bisschop, Charlotte N.Steins
AU - Travier, Noemie
AU - Van Den Buijs, Bram J.W.
AU - Backx, Frank J.G.
AU - Los, Maartje
AU - Erdkamp, Frans L.G.
AU - Bloemendal, Haiko J.
AU - Koopman, Miriam
AU - De Roos, Marnix A.J.
AU - Verhaar, Marlies J.
AU - Ten Bokkel-Huinink, Daan
AU - Van Der Wall, Elsken
AU - Peeters, Petra H.M.
AU - May, Anne M.
N1 - Publisher Copyright:
© 2015 by the American College of Sports Medicine.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Purpose Fatigue is a common problem among colon cancer patients and typically increases during chemotherapy. Exercise during chemotherapy might have beneficial effects on fatigue. To investigate the short- and long-term effects of an exercise program in colon cancer patients during adjuvant treatment, the Physical Activity During Cancer Treatment study was conducted. Methods In this multicenter randomized controlled trial, 33 colon cancer patients undergoing chemotherapy (21 men and 12 women) were randomly assigned to either a group receiving an 18-wk supervised exercise program (n = 17) or to usual care (n = 16). The primary outcome was fatigue as measured by the Multidimensional Fatigue Inventory and the Fatigue Quality List. Secondary outcomes were quality of life, physical fitness, anxiety, depression, body weight, and chemotherapy completion rate. Outcome assessment took place at baseline, postintervention (18 wk) and at 36 wk. Results Intention-to-treat mixed linear model analyses showed that patients in the intervention group experienced significantly less physical fatigue at 18 wk and general fatigue at 36 wk (mean between group differences, -3.2; 95% confidence interval [CI], -6.2 to -0.2; effect size [ES], -0.9 and -2.7; 95% CI, -5.2 to -0.1; ES, -0.8, respectively), and reported higher physical functioning (12.3; 95% CI, 3.3-21.4; ES, 1.0) compared with patients in the usual care group. Conclusion The Physical Activity During Cancer Treatment trial shows that an 18-wk supervised exercise program in colon cancer patients during chemotherapy is safe and feasible. The intervention significantly reduced physical fatigue at 18 wk and general fatigue at 36 wk. Considering the number of patients included in the present study, replication in a larger study population is required.
AB - Purpose Fatigue is a common problem among colon cancer patients and typically increases during chemotherapy. Exercise during chemotherapy might have beneficial effects on fatigue. To investigate the short- and long-term effects of an exercise program in colon cancer patients during adjuvant treatment, the Physical Activity During Cancer Treatment study was conducted. Methods In this multicenter randomized controlled trial, 33 colon cancer patients undergoing chemotherapy (21 men and 12 women) were randomly assigned to either a group receiving an 18-wk supervised exercise program (n = 17) or to usual care (n = 16). The primary outcome was fatigue as measured by the Multidimensional Fatigue Inventory and the Fatigue Quality List. Secondary outcomes were quality of life, physical fitness, anxiety, depression, body weight, and chemotherapy completion rate. Outcome assessment took place at baseline, postintervention (18 wk) and at 36 wk. Results Intention-to-treat mixed linear model analyses showed that patients in the intervention group experienced significantly less physical fatigue at 18 wk and general fatigue at 36 wk (mean between group differences, -3.2; 95% confidence interval [CI], -6.2 to -0.2; effect size [ES], -0.9 and -2.7; 95% CI, -5.2 to -0.1; ES, -0.8, respectively), and reported higher physical functioning (12.3; 95% CI, 3.3-21.4; ES, 1.0) compared with patients in the usual care group. Conclusion The Physical Activity During Cancer Treatment trial shows that an 18-wk supervised exercise program in colon cancer patients during chemotherapy is safe and feasible. The intervention significantly reduced physical fatigue at 18 wk and general fatigue at 36 wk. Considering the number of patients included in the present study, replication in a larger study population is required.
KW - COLON CANCER
KW - EXERCISE THERAPY
KW - FATIGUE
KW - RANDOMIZED CONTROLLED TRIAL
UR - http://www.scopus.com/inward/record.url?scp=84951309795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951309795&partnerID=8YFLogxK
U2 - 10.1249/MSS.0000000000000855
DO - 10.1249/MSS.0000000000000855
M3 - Article
C2 - 26694846
AN - SCOPUS:84951309795
SN - 0195-9131
VL - 48
SP - 767
EP - 775
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
IS - 5
ER -