Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment

Michela Gallagher; Jennifer L. Bizon; Eileen C. Hoyt; Katherine A. Helm; Pauline K. Lund

doi:10.1016/S0531-5565(02)00159-6

Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment

Michela Gallagher, Jennifer L. Bizon, Eileen C. Hoyt, Katherine A. Helm, Pauline K. Lund

Krieger School of Arts and Sciences

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Vertical integration is being used to great advantage in neurobiological research on the basis of age-related cognitive decline. Such research bridges analysis between the molecular and cellular levels and the outcome of impaired psychological functions. Current use of animals models within this paradigm has defined mild cognitive impairment in a subpopulation of outbred aged Long-Evans rats by assessment of hippocampal-dependent spatial cognition. Aged rats with cognitive impairment exhibited no loss of neurons in the hippocampus. Current research is focused on the functional alterations in neurons by methods which assess transcriptional mechanisms and signaling pathways.

Original language	English (US)
Pages (from-to)	71-77
Number of pages	7
Journal	Experimental Gerontology
Volume	38
Issue number	1-2
DOIs	https://doi.org/10.1016/S0531-5565(02)00159-6
State	Published - Jan 1 2003

Keywords

Glucocorticoids
Hippocampus
NFκB
Rats
Spatial memory
Synaptic protein

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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Effects of aging on the hippocampal formation in a naturally occurring animal model of mild cognitive impairment

Abstract

Keywords

ASJC Scopus subject areas

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