Effects of a dose increase on chronic opiate use during methadone detoxification

M. L. Stitzer, M. E. McCaul, G. E. Bigelow, I. A. Liebson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The purpose of the present study was to evaluate the effects on illicit opiate drug use and treatment retention of adminstering high methadone doses during detoxification treatment to chronic opiate supplementers. Patients were exposed to methadone doses which would provide an adequate blockade of opiate drug effects while suppressing the withdrawal symptoms which might result from cessation of illicit drug use. Raising the methadone dose to levels characteristic of maintenance treatment (50 - 60 mg/day) during the early weeks of a detox program resulted in improved treatment retention and decreased rates of opiate-positive urine test results in chronic opiate supplementers.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalNIDA Research Monograph Series
VolumeNO. 55
StatePublished - 1985

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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