Abstract
The effect of 21-aminosteroid, a lazaroid (U74389F), on tissue injury after secondary ischemia was evaluated in 3X5 cm island skin flaps in male Sprague-Dawley rats (n = 30). Primary ischemia was produced by arteriovenous occlusion for 1 hour. Eighteen hours later, secondary ischemia was inflicted by 4-hour venous occlusion. The treatment group received intravenous lazaroid (3 mg/kg) 30 minutes before the start of secondary ischemia. The control group received the same volume of citrate buffer vehicle using the same route and schedule. Skin-flap survival was an all-or-none phenomenon and assessed at 7 days after secondary ischemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 661-666 |
| Number of pages | 6 |
| Journal | Plastic and reconstructive surgery |
| Volume | 94 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1994 |
| Externally published | Yes |
ASJC Scopus subject areas
- Surgery