Effects of 21-aminosteroid u74389f on skin-flap survival after secondary ischemia

Myoung Soo Shin, Michael F. Angel, Michael J. Im, Paul N. Manson

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The effect of 21-aminosteroid, a lazaroid (U74389F), on tissue injury after secondary ischemia was evaluated in 3X5 cm island skin flaps in male Sprague-Dawley rats (n = 30). Primary ischemia was produced by arteriovenous occlusion for 1 hour. Eighteen hours later, secondary ischemia was inflicted by 4-hour venous occlusion. The treatment group received intravenous lazaroid (3 mg/kg) 30 minutes before the start of secondary ischemia. The control group received the same volume of citrate buffer vehicle using the same route and schedule. Skin-flap survival was an all-or-none phenomenon and assessed at 7 days after secondary ischemia.

Original languageEnglish (US)
Pages (from-to)661-666
Number of pages6
JournalPlastic and reconstructive surgery
Issue number5
StatePublished - Oct 1994
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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