Abstract
Transgenic (Tg) mice carrying a T-cell receptor (TCR) specific for a CD8+ T-cell epitope expressed in pre-erythrocytic stages of Plasmodium yoelii has proven to be a valuable tool to advance our understanding of this anti-parasite T-cell response, as it occurs in vivo. The visualization of CD8+ T cells in vivo and ex vivo greatly facilitated research aimed at characterizing basic features of this T-cell response such as the kinetics of differentiation and proliferation and the in vivo antigen presentation. Importantly, this research unveiled the existence of early self-regulatory mechanisms controlling the magnitude of the CD8+ T-cell response and also identified CD4+ T cells as critical elements in the development of memory populations. This review discusses our recent research using Tg mice and highlights our progress in understanding the CD8 + T-cell-mediated immunity against malaria liver stages.
Original language | English (US) |
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Pages (from-to) | 291-303 |
Number of pages | 13 |
Journal | Immunological reviews |
Volume | 201 |
DOIs | |
State | Published - Oct 2004 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology