Effector and memory CD8+ T cells as seen in immunity to malaria

Alexandre Morrot, Fidel Zavala

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Transgenic (Tg) mice carrying a T-cell receptor (TCR) specific for a CD8+ T-cell epitope expressed in pre-erythrocytic stages of Plasmodium yoelii has proven to be a valuable tool to advance our understanding of this anti-parasite T-cell response, as it occurs in vivo. The visualization of CD8+ T cells in vivo and ex vivo greatly facilitated research aimed at characterizing basic features of this T-cell response such as the kinetics of differentiation and proliferation and the in vivo antigen presentation. Importantly, this research unveiled the existence of early self-regulatory mechanisms controlling the magnitude of the CD8+ T-cell response and also identified CD4+ T cells as critical elements in the development of memory populations. This review discusses our recent research using Tg mice and highlights our progress in understanding the CD8 + T-cell-mediated immunity against malaria liver stages.

Original languageEnglish (US)
Pages (from-to)291-303
Number of pages13
JournalImmunological reviews
Volume201
DOIs
StatePublished - Oct 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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