Effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan Africa

Catherine G. Sutcliffe, Janneke H. van Dijk, Carolyn Bolton, Deborah Persaud, William J. Moss

Research output: Contribution to journalReview articlepeer-review

214 Scopus citations


Assessment of antiretroviral treatment programmes for HIV-infected children in sub-Saharan Africa is important to enable the development of effective care and improve treatment outcomes. We review the effectiveness of paediatric antiretroviral treatment programmes in sub-Saharan Africa and discuss the implications of these findings for the care and treatment of HIV-infected children in this region. Available reports indicate that programmes in sub-Saharan Africa achieve treatment outcomes similar to those in North America and Europe. However, progress in several areas is required to improve the care of HIV-infected children in sub-Saharan Africa. The findings emphasise the need for low-cost diagnostic tests that allow for earlier identification of HIV infection in infants living in sub-Saharan Africa, improved access to antiretroviral treatment programmes, including expansion of care into rural areas, and the integration of antiretroviral treatment programmes with other health-care services, such as nutritional support.

Original languageEnglish (US)
Pages (from-to)477-489
Number of pages13
JournalThe Lancet Infectious Diseases
Issue number8
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Infectious Diseases


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