@article{7bf7e144561a4f1db98ef9ca2d69e6de,
title = "Effect of Vitreomacular Adhesion on Treatment Outcomes in the Ranibizumab for Edema of the Macula in Diabetes (READ-3) Study",
abstract = "Purpose To assess the role of vitreomacular adhesion (VMA) in visual and anatomic outcomes in patients with diabetic macular edema (DME). Design Retrospective cohort study. Participants Data from patients enrolled in the Ranibizumab for Edema of the Macula in Diabetes: Protocol 3 with High Dose (READ-3) study were analyzed. Methods In the READ-3 study, patients with DME received monthly intravitreal injections of either 0.5 or 2.0 mg ranibizumab. Optical coherence tomography images from patients who completed the month 6 visit of the study were analyzed at the baseline visit to identify the presence (VMA+) or absence (VMA-) of VMA. Patients with any degree of vitreomacular traction were excluded from the analysis. Two independent graders graded all images. Vitreomacular adhesion was classified by size of adhesion into either focal (<1500 μm) or broad (≥1500 μm). Main Outcome Measures Mean changes in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) at month 6 and incidence of posterior vitreous detachment (PVD). Results One hundred fifty-two eyes (152 patients) were randomized in the READ-3 study. One hundred twenty-four eyes (124 patients) were eligible for the study based on study criteria. Twenty-eight eyes did not meet study criteria and were excluded from the study. At baseline, 26 patients were classified as VMA+ and 98 patients were classified as VMA-. The distribution of the 2 doses of ranibizumab (0.5 and 2.0 mg) in the 2 groups was similar. At month 6, the mean improvement in BCVA was 11.31±6.67 and 6.86±7.58 letters in the VMA+ and VMA- groups, respectively (P = 0.007). Mean improvement in CRT was -173.81±132.31 and -161.84±131.34 μm in the VMA+ and VMA- groups, respectively (P = 0.681). At month 6, among the 26 VMA+ eyes (at baseline), 7 eyes demonstrated PVD, 17 eyes showed no change in VMA status, and 2 eyes were not gradable and were excluded. Conclusions Diabetic macular edema patients with VMA have a greater potential for improvement in visual outcomes with anti-vascular endothelial growth factor therapy. Therefore, the presence of VMA should not preclude patients with DME from receiving treatment.",
author = "{READ-3 Study Group} and Sadiq, {Mohammad Ali} and Soliman, {Mohamed Kamel} and Salman Sarwar and Aniruddha Agarwal and Mostafa Hanout and Sibel Demirel and Rentiya, {Zubir S.} and Waqar Khan and Do, {Diana V.} and Nguyen, {Quan Dong} and Sepah, {Yasir J.}",
note = "Funding Information: The Ranibizumab for Edema of the Macula in Diabetes: Protocol 3 with High Dose (READ-3) study was an investigator-sponsored study, with the investigative new drug for the study held by one of the investigators (Q.D.N.). The READ-3 Study was funded by Juvenile Diabetes Research Foundation International with the study drug provided by Genentech, Inc. The index study was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc., New York, New York, to the Truhlsen Eye Institute at the University of Nebraska Medical Center. Dr. Nguyen is a recipient of a Physician Scientist Award from Research to Prevent Blindness. Funding Information: The author(s) have made the following disclosure(s): Q.D.N.: Consultant Bausch&Lomb (Rochester, NY); Santen (Osaka, Japan); Financial support Genentech (San Francisco, CA); MacuSight (Union City, CA); Santen; L-Path (San Diego, CA); Ophthotech (Princeton, NJ); Regeneron (Tarrytown, NY); Institutional Consulting AbbVie (Chicago, IL); Honorarium Bayer (Leverkusen, Germany); XOMA (Berkeley, CA); Heidelberg (Heidelberg, Germany); Quantel (Les Ulis, France); Steering Committee RISE and RIDE Study, VISTA Study, and other studies sponsored by Genentech and Regeneron D.V.D.: Consultant Genentech (San Francisco, CA); Regeneron (Tarrytown, NY); Santen (Osaka, Japan); Allergan (Irvine, CA); Financial support - Genentech; Regeneron; Honorarium Heidelberg (Heidelberg, Germany); Quantel (Les Ulis, France); Steering Committee VISTA Study The Ranibizumab for Edema of the Macula in Diabetes: Protocol 3 with High Dose (READ-3) study was an investigator-sponsored study, with the investigative new drug for the study held by one of the investigators (Q.D.N.). The READ-3 Study was funded by Juvenile Diabetes Research Foundation International with the study drug provided by Genentech, Inc. The index study was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc., New York, New York, to the Truhlsen Eye Institute at the University of Nebraska Medical Center. Dr. Nguyen is a recipient of a Physician Scientist Award from Research to Prevent Blindness. Publisher Copyright: {\textcopyright} 2016 American Academy of Ophthalmology.",
year = "2016",
doi = "10.1016/j.ophtha.2015.09.032",
language = "English (US)",
volume = "123",
pages = "324--329",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "2",
}