Effect of urbanisation on the relationship between total serum IgE and asthma

William Checkley; Colin L. Robinson; Lauren M. Baumann; Karina Romero; Juan M. Combe; Robert H. Gilman; Robert A. Wise; Robert G. Hamilton; Guillermo Gonzalvez; Vitaliano Cama; Nadia N. Hansel

doi:10.1183/09031936.00025512

Effect of urbanisation on the relationship between total serum IgE and asthma

William Checkley, Colin L. Robinson, Lauren M. Baumann, Karina Romero, Juan M. Combe, Robert H. Gilman, Robert A. Wise, Robert G. Hamilton, Guillermo Gonzalvez, Vitaliano Cama, Nadia N. Hansel

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

It is unclear if the relationship of total serum IgE with asthma varies with degree of urbanisation. We hypothesised that the relationship of total serum IgE to asthma is more pronounced in an urban versus a rural environment. We enrolled 1441 children aged 13-15 years in a peri-urban shanty town in Lima, Peru (n=725) and 23 villages in rural Tumbes, Peru (n=716). We asked participants about asthma and allergy symptoms, environmental exposures and sociodemographics; and performed spirometry, and exhaled nitric oxide and allergy skin testing. We obtained blood for total serum IgE in 1143 (79%) participants. Geometric means for total serum IgE were higher in Lima versus Tumbes (262 versus 192 kU·L^-1; p<0.001). The odds of asthma increased by factors of 1.6 (95% CI 1.3-2.0) versus 1.4 (95% CI 0.9-2.1) per log unit increase in total serum IgE in Lima versus Tumbes, respectively. Atopy was an effect modifier of the relationship of total serum IgE on asthma. Among atopics and non-atopics, the odds of asthma increased by a factor of 2.0 (95% CI 1.5-2.7) and 1.0 (95% CI 0.7-1.4) per log unit increase in total serum IgE, respectively. Total serum IgE was associated with atopic asthma but not with non-atopic asthma. Urbanisation did not appear to be an effect modifier of this relationship. Copyright

Original language	English (US)
Pages (from-to)	1074-1081
Number of pages	8
Journal	European Respiratory Journal
Volume	41
Issue number	5
DOIs	https://doi.org/10.1183/09031936.00025512
State	Published - May 1 2013

Keywords

Asthma clinical/basic investigations
Atopic asthma
Epidemiology of asthma

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1183/09031936.00025512

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title = "Effect of urbanisation on the relationship between total serum IgE and asthma",

abstract = "It is unclear if the relationship of total serum IgE with asthma varies with degree of urbanisation. We hypothesised that the relationship of total serum IgE to asthma is more pronounced in an urban versus a rural environment. We enrolled 1441 children aged 13-15 years in a peri-urban shanty town in Lima, Peru (n=725) and 23 villages in rural Tumbes, Peru (n=716). We asked participants about asthma and allergy symptoms, environmental exposures and sociodemographics; and performed spirometry, and exhaled nitric oxide and allergy skin testing. We obtained blood for total serum IgE in 1143 (79%) participants. Geometric means for total serum IgE were higher in Lima versus Tumbes (262 versus 192 kU·L-1; p<0.001). The odds of asthma increased by factors of 1.6 (95% CI 1.3-2.0) versus 1.4 (95% CI 0.9-2.1) per log unit increase in total serum IgE in Lima versus Tumbes, respectively. Atopy was an effect modifier of the relationship of total serum IgE on asthma. Among atopics and non-atopics, the odds of asthma increased by a factor of 2.0 (95% CI 1.5-2.7) and 1.0 (95% CI 0.7-1.4) per log unit increase in total serum IgE, respectively. Total serum IgE was associated with atopic asthma but not with non-atopic asthma. Urbanisation did not appear to be an effect modifier of this relationship. Copyright",

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author = "William Checkley and Robinson, {Colin L.} and Baumann, {Lauren M.} and Karina Romero and Combe, {Juan M.} and Gilman, {Robert H.} and Wise, {Robert A.} and Hamilton, {Robert G.} and Guillermo Gonzalvez and Vitaliano Cama and Hansel, {Nadia N.}",

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AU - Checkley, William

AU - Robinson, Colin L.

AU - Baumann, Lauren M.

AU - Romero, Karina

AU - Combe, Juan M.

AU - Gilman, Robert H.

AU - Wise, Robert A.

AU - Hamilton, Robert G.

AU - Gonzalvez, Guillermo

AU - Cama, Vitaliano

AU - Hansel, Nadia N.

PY - 2013/5/1

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N2 - It is unclear if the relationship of total serum IgE with asthma varies with degree of urbanisation. We hypothesised that the relationship of total serum IgE to asthma is more pronounced in an urban versus a rural environment. We enrolled 1441 children aged 13-15 years in a peri-urban shanty town in Lima, Peru (n=725) and 23 villages in rural Tumbes, Peru (n=716). We asked participants about asthma and allergy symptoms, environmental exposures and sociodemographics; and performed spirometry, and exhaled nitric oxide and allergy skin testing. We obtained blood for total serum IgE in 1143 (79%) participants. Geometric means for total serum IgE were higher in Lima versus Tumbes (262 versus 192 kU·L-1; p<0.001). The odds of asthma increased by factors of 1.6 (95% CI 1.3-2.0) versus 1.4 (95% CI 0.9-2.1) per log unit increase in total serum IgE in Lima versus Tumbes, respectively. Atopy was an effect modifier of the relationship of total serum IgE on asthma. Among atopics and non-atopics, the odds of asthma increased by a factor of 2.0 (95% CI 1.5-2.7) and 1.0 (95% CI 0.7-1.4) per log unit increase in total serum IgE, respectively. Total serum IgE was associated with atopic asthma but not with non-atopic asthma. Urbanisation did not appear to be an effect modifier of this relationship. Copyright

AB - It is unclear if the relationship of total serum IgE with asthma varies with degree of urbanisation. We hypothesised that the relationship of total serum IgE to asthma is more pronounced in an urban versus a rural environment. We enrolled 1441 children aged 13-15 years in a peri-urban shanty town in Lima, Peru (n=725) and 23 villages in rural Tumbes, Peru (n=716). We asked participants about asthma and allergy symptoms, environmental exposures and sociodemographics; and performed spirometry, and exhaled nitric oxide and allergy skin testing. We obtained blood for total serum IgE in 1143 (79%) participants. Geometric means for total serum IgE were higher in Lima versus Tumbes (262 versus 192 kU·L-1; p<0.001). The odds of asthma increased by factors of 1.6 (95% CI 1.3-2.0) versus 1.4 (95% CI 0.9-2.1) per log unit increase in total serum IgE in Lima versus Tumbes, respectively. Atopy was an effect modifier of the relationship of total serum IgE on asthma. Among atopics and non-atopics, the odds of asthma increased by a factor of 2.0 (95% CI 1.5-2.7) and 1.0 (95% CI 0.7-1.4) per log unit increase in total serum IgE, respectively. Total serum IgE was associated with atopic asthma but not with non-atopic asthma. Urbanisation did not appear to be an effect modifier of this relationship. Copyright

KW - Asthma clinical/basic investigations

KW - Atopic asthma

KW - Epidemiology of asthma

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EP - 1081

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 5

ER -

Effect of urbanisation on the relationship between total serum IgE and asthma

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