Effect of Topical Mitomycin C on Glaucoma Filtration Surgery in Monkeys

Louis R. Pasquale; Diane Thibault; Mary Ellen Dorman-Pease; Harry A. Quigley; Henry D. Jampel

doi:10.1016/S0161-6420(92)32025-1

Effect of Topical Mitomycin C on Glaucoma Filtration Surgery in Monkeys

Louis R. Pasquale, Diane Thibault, Mary Ellen Dorman-Pease, Harry A. Quigley, Henry D. Jampel

School of Medicine

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

In this study, an experimental model of glaucoma filtration surgery was used to evaluate the clinical and histologic effects of a single intraoperative topical application of mitomycin C. Argon laser treatment to the trabecular meshwork produced sustained elevation of intraocular pressure in monkeys. Eight eyes of four animals were randomly assigned to receive topical mitomycin C or balanced salt solution at the time of fullthickness sclerostomy. Surgical success was substantially increased in four of five eyes that received mitomycin C when compared with three eyes that received topical balanced salt solution. Mitomycin C was also effective in prolonging surgical success in two eyes that had previously undergone surgery and failed. No significant ocular toxicity was observed in eyes treated with mitomycin C. Histologic examination of mitomycin Ctreated eyes showed patent sclerostomies and hypocellular, well-formed bleb cavities. A single intraoperative application of mitomycin C has a marked effect on postoperative wound healing after filtration surgery in monkeys.

Original language	English (US)
Pages (from-to)	14-18
Number of pages	5
Journal	Ophthalmology
Volume	99
Issue number	1
DOIs	https://doi.org/10.1016/S0161-6420(92)32025-1
State	Published - 1992

ASJC Scopus subject areas

Ophthalmology

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title = "Effect of Topical Mitomycin C on Glaucoma Filtration Surgery in Monkeys",

abstract = "In this study, an experimental model of glaucoma filtration surgery was used to evaluate the clinical and histologic effects of a single intraoperative topical application of mitomycin C. Argon laser treatment to the trabecular meshwork produced sustained elevation of intraocular pressure in monkeys. Eight eyes of four animals were randomly assigned to receive topical mitomycin C or balanced salt solution at the time of fullthickness sclerostomy. Surgical success was substantially increased in four of five eyes that received mitomycin C when compared with three eyes that received topical balanced salt solution. Mitomycin C was also effective in prolonging surgical success in two eyes that had previously undergone surgery and failed. No significant ocular toxicity was observed in eyes treated with mitomycin C. Histologic examination of mitomycin Ctreated eyes showed patent sclerostomies and hypocellular, well-formed bleb cavities. A single intraoperative application of mitomycin C has a marked effect on postoperative wound healing after filtration surgery in monkeys.",

author = "Pasquale, {Louis R.} and Diane Thibault and Dorman-Pease, {Mary Ellen} and Quigley, {Harry A.} and Jampel, {Henry D.}",

note = "Funding Information: Supported by NIH grants EY07047, EY02120, and EY01765, Bethesda, Maryland, and a grant from the National Glaucoma Research, a division of the American Health Assistance Foundation, Rockville, Maryland, The authors have no proprietary interest in any of the products mentioned in this study.",

year = "1992",

doi = "10.1016/S0161-6420(92)32025-1",

language = "English (US)",

volume = "99",

pages = "14--18",

journal = "Ophthalmology",

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AU - Pasquale, Louis R.

AU - Thibault, Diane

AU - Dorman-Pease, Mary Ellen

AU - Quigley, Harry A.

AU - Jampel, Henry D.

N1 - Funding Information: Supported by NIH grants EY07047, EY02120, and EY01765, Bethesda, Maryland, and a grant from the National Glaucoma Research, a division of the American Health Assistance Foundation, Rockville, Maryland, The authors have no proprietary interest in any of the products mentioned in this study.

PY - 1992

Y1 - 1992

N2 - In this study, an experimental model of glaucoma filtration surgery was used to evaluate the clinical and histologic effects of a single intraoperative topical application of mitomycin C. Argon laser treatment to the trabecular meshwork produced sustained elevation of intraocular pressure in monkeys. Eight eyes of four animals were randomly assigned to receive topical mitomycin C or balanced salt solution at the time of fullthickness sclerostomy. Surgical success was substantially increased in four of five eyes that received mitomycin C when compared with three eyes that received topical balanced salt solution. Mitomycin C was also effective in prolonging surgical success in two eyes that had previously undergone surgery and failed. No significant ocular toxicity was observed in eyes treated with mitomycin C. Histologic examination of mitomycin Ctreated eyes showed patent sclerostomies and hypocellular, well-formed bleb cavities. A single intraoperative application of mitomycin C has a marked effect on postoperative wound healing after filtration surgery in monkeys.

AB - In this study, an experimental model of glaucoma filtration surgery was used to evaluate the clinical and histologic effects of a single intraoperative topical application of mitomycin C. Argon laser treatment to the trabecular meshwork produced sustained elevation of intraocular pressure in monkeys. Eight eyes of four animals were randomly assigned to receive topical mitomycin C or balanced salt solution at the time of fullthickness sclerostomy. Surgical success was substantially increased in four of five eyes that received mitomycin C when compared with three eyes that received topical balanced salt solution. Mitomycin C was also effective in prolonging surgical success in two eyes that had previously undergone surgery and failed. No significant ocular toxicity was observed in eyes treated with mitomycin C. Histologic examination of mitomycin Ctreated eyes showed patent sclerostomies and hypocellular, well-formed bleb cavities. A single intraoperative application of mitomycin C has a marked effect on postoperative wound healing after filtration surgery in monkeys.

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Effect of Topical Mitomycin C on Glaucoma Filtration Surgery in Monkeys

Abstract

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