Abstract
Objective: To investigate the efficacy of Tanakan, Ginkgo biloba extract, in neonatal rat hypoxic-ischemic brain damage. Methods: Hypoxia-ischemia was induced in rat pups by performing a delayed cesarean section on the last day of pregnant Sprague-Dawley rats. Tanakan (one kind of Ginkgo biloba extract) 100 mg·kg-1 added to the pups for 2 days. Pregnant at the sixteenth day SD female rats were treated with 100 mg·kg-1 Tanakan for 5 days. Then they were performed the same operation. Litters delivered by cesarean section without producing hypoxic-ischemic were used as controls. We examine platelet activating factor content in the pup brain tissues. Results: Electron-microscopic observations showed hypoxic-ischemic changes in the neuron of model rats. And the damage was lessened in the neuron of pretreatment or therapy group. The content of PAF was significant increase in hypoxic-ischemic model rats (P<0.01). Pretreatment or therapy with Tanakan pups showed a significant reduction in PAF levels. And PAF levels in pretreatment pups was lower than that in therapy pups. Conclusion: Tanakan can protect the neonatal brain when hypoxia-ischemic brain damage happens. And pretreat with Tanakan is better than that of therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 299-301+313 |
| Journal | Journal of Xi'an Medical University, Chinese Edition |
| Volume | 23 |
| Issue number | 3 |
| State | Published - 2002 |
| Externally published | Yes |
Keywords
- Ginkgo biloba extract
- Hypoxic-ischemic brain damage
- Neonatal rats
- Platelet activating factor
ASJC Scopus subject areas
- General Medicine