TY - JOUR
T1 - Effect of smoking on the clinical progression of HIV-1 infection
AU - Galai, Noya
AU - Park, Lawrence P.
AU - Wesch, Jerry
AU - Visscher, Barbara
AU - Riddler, Sharon
AU - Margolick, Joseph B.
PY - 1997/4/15
Y1 - 1997/4/15
N2 - Cigarette smoking as a risk factor in progression of HIV-1 disease was investigated in the Multicenter AIDS Cohort Study of homosexual men. Longitudinal data for T-cell subsets, HIV-related clinical symptoms, smoking behavior, and AIDS medication use were collected semiannually from 2,499 HIV- 1-seropositive men for up to 9 years. Survival methods, including Kaplan- Meier analysis and multivariate Cox regression models, were used to assess the effect of cigarette smoking on development of Pneumocystis carinii pneumonia (PCP), AIDS, death, and self-reported oral thrush. After adjustment for CD4+ lymphocyte count and use of antiretroviral and anti-PCP medications, smoking was not significantly associated with progression to PCP, AIDS, or death in either the HIV-seroprevalent or-seroincident cohort members. Among men who had baseline CD4+ cell counts >200/μl, smoking was associated with a 40% increase in the hazard of oral thrush (p ≤ 0.01). These data indicate that cigarette smoking does not have a major effect on the progression of HIV-1 infection to AIDS or death but may affect the incidence of oral thrush.
AB - Cigarette smoking as a risk factor in progression of HIV-1 disease was investigated in the Multicenter AIDS Cohort Study of homosexual men. Longitudinal data for T-cell subsets, HIV-related clinical symptoms, smoking behavior, and AIDS medication use were collected semiannually from 2,499 HIV- 1-seropositive men for up to 9 years. Survival methods, including Kaplan- Meier analysis and multivariate Cox regression models, were used to assess the effect of cigarette smoking on development of Pneumocystis carinii pneumonia (PCP), AIDS, death, and self-reported oral thrush. After adjustment for CD4+ lymphocyte count and use of antiretroviral and anti-PCP medications, smoking was not significantly associated with progression to PCP, AIDS, or death in either the HIV-seroprevalent or-seroincident cohort members. Among men who had baseline CD4+ cell counts >200/μl, smoking was associated with a 40% increase in the hazard of oral thrush (p ≤ 0.01). These data indicate that cigarette smoking does not have a major effect on the progression of HIV-1 infection to AIDS or death but may affect the incidence of oral thrush.
KW - AIDS
KW - Cigarette smoking
KW - HIV-1 disease progression
KW - Oral thrush
UR - http://www.scopus.com/inward/record.url?scp=0030995375&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030995375&partnerID=8YFLogxK
U2 - 10.1097/00042560-199704150-00009
DO - 10.1097/00042560-199704150-00009
M3 - Article
C2 - 9170420
AN - SCOPUS:0030995375
SN - 1077-9450
VL - 14
SP - 451
EP - 458
JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
IS - 5
ER -