TY - JOUR
T1 - Effect of sleep on gastroesophageal physiology and airway protective mechanisms
AU - Pasricha, P. Jay
PY - 2003/8/18
Y1 - 2003/8/18
N2 - The sleeping state is accompanied by many changes in gastroesophageal function that may be of importance in the pathogenesis of gastroesophageal reflux disease (GERD). At nighttime, gastric acid production is increased, gastric emptying is delayed, esophageal clearance is markedly delayed, and upper esophageal sphincter pressure diminishes significantly. Further, unlike daytime esophageal acid exposure, which appears more easily controlled with medical treatment, nocturnal gastric acid production appears difficult to suppress pharmacologically. Nighttime reflux may be associated with a greater prevalence of supraesophageal reflux symptoms as well. At the same time, protective airway reflexes may limit esophageal reflux in some patients. Derangements in the protective mechanisms should be elucidated, as these might account for susceptibility to GERD in patients with nighttime reflux.
AB - The sleeping state is accompanied by many changes in gastroesophageal function that may be of importance in the pathogenesis of gastroesophageal reflux disease (GERD). At nighttime, gastric acid production is increased, gastric emptying is delayed, esophageal clearance is markedly delayed, and upper esophageal sphincter pressure diminishes significantly. Further, unlike daytime esophageal acid exposure, which appears more easily controlled with medical treatment, nocturnal gastric acid production appears difficult to suppress pharmacologically. Nighttime reflux may be associated with a greater prevalence of supraesophageal reflux symptoms as well. At the same time, protective airway reflexes may limit esophageal reflux in some patients. Derangements in the protective mechanisms should be elucidated, as these might account for susceptibility to GERD in patients with nighttime reflux.
UR - http://www.scopus.com/inward/record.url?scp=0042659612&partnerID=8YFLogxK
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U2 - 10.1016/S0002-9343(03)00208-0
DO - 10.1016/S0002-9343(03)00208-0
M3 - Article
C2 - 12928086
AN - SCOPUS:0042659612
SN - 0002-9343
VL - 115
SP - 114
EP - 118
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 3 SUPPL. 1
ER -