Effect of obesity on clinical presentation and response to treatment in asthma

Anne E. Dixon, David M. Shade, Rubin I. Cohen, Gwen S. Skloot, Janet T. Holbrook, Lewis J. Smith, John J. Lima, Hooman Allayee, Charles G. Irvin, Robert A. Wise

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.

Original languageEnglish (US)
Pages (from-to)553-558
Number of pages6
JournalJournal of Asthma
Issue number7
StatePublished - Aug 1 2006


  • Asthma
  • Gastroesophageal reflux disease
  • Obesity
  • Spirometry
  • Theophylline

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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