TY - JOUR
T1 - Effect of memory impairment on training outcomes in ACTIVE
AU - Univerzagt, Frederick W.
AU - Kasten, Linda
AU - Johnson, Kathy E.
AU - Rebok, George W.
AU - Marsiske, Michael
AU - Koepke, Kathy Mann
AU - Elias, Jeffrey W.
AU - Morris, John N.
AU - Willis, Sherry L.
AU - Ball, Karlene
AU - Rexroth, Daniel F.
AU - Smith, David M.
AU - Wolinsky, Fredric D.
AU - Tennstedt, Sharon L.
PY - 2007/11
Y1 - 2007/11
N2 - Cognitive training improves mental abilities in older adults, but the trainability of persons with memory impairment is unclear. We conducted a subgroup analysis of subjects in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial to examine this issue. ACTIVE enrolled 2802 non-demented, community-dwelling adults aged 65 years and older and randomly assigned them to one of four groups: Memory training, reasoning training, speed-of-processing training, or no-contact control. For this study, participants were defined as memory-impaired if baseline Rey Auditory Verbal Learning Test (AVLT) sum recall score was 1.5 SD or more below predicted AVLT sum recall score from a regression-derived formula using age, education, ethnicity, and vocabulary from all subjects at baseline. Assessments were taken at baseline (BL), post-test, first annual (A1), and second annual (A2) follow-up. One hundred and ninety-three subjects were defined as memory-impaired and 2580 were memory-normal. Training gain as a function memory status (impaired vs. normal) was compared in a mixed effects model. Results indicated that memory-impaired participants failed to benefit from Memory training but did show normal training gains after reasoning and speed training. Memory function appears to mediate response to structured cognitive interventions in older adults.
AB - Cognitive training improves mental abilities in older adults, but the trainability of persons with memory impairment is unclear. We conducted a subgroup analysis of subjects in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial to examine this issue. ACTIVE enrolled 2802 non-demented, community-dwelling adults aged 65 years and older and randomly assigned them to one of four groups: Memory training, reasoning training, speed-of-processing training, or no-contact control. For this study, participants were defined as memory-impaired if baseline Rey Auditory Verbal Learning Test (AVLT) sum recall score was 1.5 SD or more below predicted AVLT sum recall score from a regression-derived formula using age, education, ethnicity, and vocabulary from all subjects at baseline. Assessments were taken at baseline (BL), post-test, first annual (A1), and second annual (A2) follow-up. One hundred and ninety-three subjects were defined as memory-impaired and 2580 were memory-normal. Training gain as a function memory status (impaired vs. normal) was compared in a mixed effects model. Results indicated that memory-impaired participants failed to benefit from Memory training but did show normal training gains after reasoning and speed training. Memory function appears to mediate response to structured cognitive interventions in older adults.
KW - Aging
KW - Clinical trial
KW - Cognition
KW - Memory
KW - Mild cognitive impairment
KW - Psychological technique
KW - Therapeutics
UR - http://www.scopus.com/inward/record.url?scp=35448968197&partnerID=8YFLogxK
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U2 - 10.1017/S1355617707071512
DO - 10.1017/S1355617707071512
M3 - Article
C2 - 17942013
AN - SCOPUS:35448968197
SN - 1355-6177
VL - 13
SP - 953
EP - 960
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 6
ER -