Effect of memory impairment on training outcomes in ACTIVE

Frederick W. Univerzagt, Linda Kasten, Kathy E. Johnson, George W. Rebok, Michael Marsiske, Kathy Mann Koepke, Jeffrey W. Elias, John N. Morris, Sherry L. Willis, Karlene Ball, Daniel F. Rexroth, David M. Smith, Fredric D. Wolinsky, Sharon L. Tennstedt

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Cognitive training improves mental abilities in older adults, but the trainability of persons with memory impairment is unclear. We conducted a subgroup analysis of subjects in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial to examine this issue. ACTIVE enrolled 2802 non-demented, community-dwelling adults aged 65 years and older and randomly assigned them to one of four groups: Memory training, reasoning training, speed-of-processing training, or no-contact control. For this study, participants were defined as memory-impaired if baseline Rey Auditory Verbal Learning Test (AVLT) sum recall score was 1.5 SD or more below predicted AVLT sum recall score from a regression-derived formula using age, education, ethnicity, and vocabulary from all subjects at baseline. Assessments were taken at baseline (BL), post-test, first annual (A1), and second annual (A2) follow-up. One hundred and ninety-three subjects were defined as memory-impaired and 2580 were memory-normal. Training gain as a function memory status (impaired vs. normal) was compared in a mixed effects model. Results indicated that memory-impaired participants failed to benefit from Memory training but did show normal training gains after reasoning and speed training. Memory function appears to mediate response to structured cognitive interventions in older adults.

Original languageEnglish (US)
Pages (from-to)953-960
Number of pages8
JournalJournal of the International Neuropsychological Society
Issue number6
StatePublished - Nov 2007


  • Aging
  • Clinical trial
  • Cognition
  • Memory
  • Mild cognitive impairment
  • Psychological technique
  • Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health


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