TY - JOUR
T1 - Effect of mandibular position on upper airway collapsibility and resistance
AU - Inazawa, T.
AU - Ayuse, T.
AU - Kurata, S.
AU - Okayasu, I.
AU - Sakamoto, E.
AU - Oi, K.
AU - Schneider, H.
AU - Schwartz, A. R.
PY - 2005/6
Y1 - 2005/6
N2 - It has been proposed that advancement of the mandible is a useful method for decreasing upper airway collapsibility. We carried out this study to test the hypothesis that mandibular advancement induces changes in upper airway patency during midazolam sedation. To explore its effect, we examined upper airway pressure-flow relationships in each of 4 conditions of mouth position in normal, healthy subjects (n = 9). In the neutral position, Pcrit (i.e., critical closing pressure, an index of upper airway collapsibility) was -4.2 cm H 2O, and upstream resistance (Rua) was 21.2 cm H2O/L/sec. In the centric occlusal position, Pcrit was -7.1 cm H2O, and Rua was 16.6 cm H2O/L/sec. In the incisor position, Pcrit was significantly reduced to -10.7 cm H2O, and Rua was significantly reduced to 14.0 cm H2O/L/sec. Mandibular advancement significantly decreased Pcrit to -13.3 cm H2O, but did not significantly influence Rua (22.1 cm H 2O/L/sec). We conclude that the mandibular incisors' position improved airway patency and decreased resistance during midazolam sedation.
AB - It has been proposed that advancement of the mandible is a useful method for decreasing upper airway collapsibility. We carried out this study to test the hypothesis that mandibular advancement induces changes in upper airway patency during midazolam sedation. To explore its effect, we examined upper airway pressure-flow relationships in each of 4 conditions of mouth position in normal, healthy subjects (n = 9). In the neutral position, Pcrit (i.e., critical closing pressure, an index of upper airway collapsibility) was -4.2 cm H 2O, and upstream resistance (Rua) was 21.2 cm H2O/L/sec. In the centric occlusal position, Pcrit was -7.1 cm H2O, and Rua was 16.6 cm H2O/L/sec. In the incisor position, Pcrit was significantly reduced to -10.7 cm H2O, and Rua was significantly reduced to 14.0 cm H2O/L/sec. Mandibular advancement significantly decreased Pcrit to -13.3 cm H2O, but did not significantly influence Rua (22.1 cm H 2O/L/sec). We conclude that the mandibular incisors' position improved airway patency and decreased resistance during midazolam sedation.
KW - Critical closing pressure
KW - Mandibular advancement
KW - Sedation
KW - Sleep apnea
KW - Upper airway
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U2 - 10.1177/154405910508400613
DO - 10.1177/154405910508400613
M3 - Article
C2 - 15914594
AN - SCOPUS:22844433455
SN - 0022-0345
VL - 84
SP - 554
EP - 558
JO - Journal of Dental Research
JF - Journal of Dental Research
IS - 6
ER -