Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women

A. A. Murphy; C. S. Cropp; B. S. Smith; R. T. Burkman; H. A. Zacur

doi:10.1016/s0015-0282(16)53212-9

Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women

A. A. Murphy, C. S. Cropp, B. S. Smith, R. T. Burkman, H. A. Zacur

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

The effectiveness of a low-dose oral contraceptive (OC) is suppressing plasma levels of gonadotropins, ovarian, and adrenal androgens and stimulating sex hormone-binding globulin (SHBG) was evaluated prospectively in nonhirsute women. Thirty-three women ingested 35 μg of ethinyl estradiol and 1 mg of norethindrone beginning within day 1 to 5 of the menstrual cycle. Baseline levels of luteinizing hormone, follicle-stimulating hormone, total testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), and SHBG were obtained before ingestion of the OC and repeated after 3, 6 and 9 months of OC use on day 1 to 5 of the OC 'cycle'. A significant suppression of gonadotropin levels is seen in nonhirsute women. Sex hormone binding globulin is consistently stimulated by the low-dose OC. A significant suppression of T and DHEAS is observed. No change was seen in levels of A. The demonstrated effects become evident at 3 months and are maintained at 6 and 9 months.

Original language	English (US)
Pages (from-to)	35-39
Number of pages	5
Journal	Fertility and sterility
Volume	53
Issue number	1
DOIs	https://doi.org/10.1016/s0015-0282(16)53212-9
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/s0015-0282(16)53212-9

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@article{870e6515d849443da5fe2bfe7c3abfda,

title = "Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women",

abstract = "The effectiveness of a low-dose oral contraceptive (OC) is suppressing plasma levels of gonadotropins, ovarian, and adrenal androgens and stimulating sex hormone-binding globulin (SHBG) was evaluated prospectively in nonhirsute women. Thirty-three women ingested 35 μg of ethinyl estradiol and 1 mg of norethindrone beginning within day 1 to 5 of the menstrual cycle. Baseline levels of luteinizing hormone, follicle-stimulating hormone, total testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), and SHBG were obtained before ingestion of the OC and repeated after 3, 6 and 9 months of OC use on day 1 to 5 of the OC 'cycle'. A significant suppression of gonadotropin levels is seen in nonhirsute women. Sex hormone binding globulin is consistently stimulated by the low-dose OC. A significant suppression of T and DHEAS is observed. No change was seen in levels of A. The demonstrated effects become evident at 3 months and are maintained at 6 and 9 months.",

author = "Murphy, {A. A.} and Cropp, {C. S.} and Smith, {B. S.} and Burkman, {R. T.} and Zacur, {H. A.}",

note = "Funding Information: Received June 12, 1989; revised and accepted August 9, 1989. * Supported in part by the General Research Center grant PHS RR-00827 and grant N01-HD-32816 from the National Institutes of Health, Bethesda, Maryland. t Presented at the Thirty-fifth Annual Meeting of the Society of Gynecologic Investigations, March 18 to 20, 1988, Baltimore, Maryland. :j: Department of Reproductive Medicine, University of California, San Diego School of Medicine. § Reprint requests: Ana A. MurPhy, M.D., UCSD Medical Center T -002, 225 Dickinson Street, San Diego, California 92103. II Present address: National Cancer Institute, Bethesda, Maryland. 1! Department of Gynecology and Obstetrics, Johns Hopkins University, School of Medicine. #Present address: Department of Obstetrics and Gynecology, Henry Ford Hospital, Detroit, Michigan.",

year = "1990",

doi = "10.1016/s0015-0282(16)53212-9",

language = "English (US)",

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journal = "Fertility and sterility",

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T1 - Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women

AU - Murphy, A. A.

AU - Cropp, C. S.

AU - Smith, B. S.

AU - Burkman, R. T.

AU - Zacur, H. A.

N1 - Funding Information: Received June 12, 1989; revised and accepted August 9, 1989. * Supported in part by the General Research Center grant PHS RR-00827 and grant N01-HD-32816 from the National Institutes of Health, Bethesda, Maryland. t Presented at the Thirty-fifth Annual Meeting of the Society of Gynecologic Investigations, March 18 to 20, 1988, Baltimore, Maryland. :j: Department of Reproductive Medicine, University of California, San Diego School of Medicine. § Reprint requests: Ana A. MurPhy, M.D., UCSD Medical Center T -002, 225 Dickinson Street, San Diego, California 92103. II Present address: National Cancer Institute, Bethesda, Maryland. 1! Department of Gynecology and Obstetrics, Johns Hopkins University, School of Medicine. #Present address: Department of Obstetrics and Gynecology, Henry Ford Hospital, Detroit, Michigan.

PY - 1990

Y1 - 1990

N2 - The effectiveness of a low-dose oral contraceptive (OC) is suppressing plasma levels of gonadotropins, ovarian, and adrenal androgens and stimulating sex hormone-binding globulin (SHBG) was evaluated prospectively in nonhirsute women. Thirty-three women ingested 35 μg of ethinyl estradiol and 1 mg of norethindrone beginning within day 1 to 5 of the menstrual cycle. Baseline levels of luteinizing hormone, follicle-stimulating hormone, total testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), and SHBG were obtained before ingestion of the OC and repeated after 3, 6 and 9 months of OC use on day 1 to 5 of the OC 'cycle'. A significant suppression of gonadotropin levels is seen in nonhirsute women. Sex hormone binding globulin is consistently stimulated by the low-dose OC. A significant suppression of T and DHEAS is observed. No change was seen in levels of A. The demonstrated effects become evident at 3 months and are maintained at 6 and 9 months.

AB - The effectiveness of a low-dose oral contraceptive (OC) is suppressing plasma levels of gonadotropins, ovarian, and adrenal androgens and stimulating sex hormone-binding globulin (SHBG) was evaluated prospectively in nonhirsute women. Thirty-three women ingested 35 μg of ethinyl estradiol and 1 mg of norethindrone beginning within day 1 to 5 of the menstrual cycle. Baseline levels of luteinizing hormone, follicle-stimulating hormone, total testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), and SHBG were obtained before ingestion of the OC and repeated after 3, 6 and 9 months of OC use on day 1 to 5 of the OC 'cycle'. A significant suppression of gonadotropin levels is seen in nonhirsute women. Sex hormone binding globulin is consistently stimulated by the low-dose OC. A significant suppression of T and DHEAS is observed. No change was seen in levels of A. The demonstrated effects become evident at 3 months and are maintained at 6 and 9 months.

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Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women

Abstract

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