TY - JOUR
T1 - Effect of laparoscopic antireflux surgery upon renal blood flow
AU - Are, Chandrakanth
AU - Kutka, Michael
AU - Talamini, Mark
AU - Hardacre, Jeffrey
AU - Mendoza-Sagaon, Mario
AU - Hanley, Eric
AU - Toung, Thomas
PY - 2002
Y1 - 2002
N2 - Background: Hypercapnia and local pressure effects unique to CO2 base minimally invasive surgery alter renal blood flow. We have demonstrated laparoscopic antireflux surgery to have an additional impact upon hemodynamics (decreased cardiac output), potentially extending known effects upon renal blood flow. Methods: We measured renal blood flow with radioactive microspheres during laparoscopic antireflux surgery in a porcine model. Six pigs were anesthetized, monitoring lines were placed, and microspheres injected five time points associated with a laparoscopic antireflux operation. After euthanasia kidneys were retrieved and fixed, and representative samples counted for radioactivity specific for each of the five time points. Results: The greatest reduction in renal blood flow was 36% below baseline (p<0.05). Concurrently, cardiac output had a maximum reduction of 39%. Conclusions: Laparoscopic Nissen fundoplication in this pig model is associated with a significant reduction in renal blood flow, probably related to reduction in cardiac output. Caution is warranted when considering laparoscopic antireflux surgery in patients with a compromised renal blood flow.
AB - Background: Hypercapnia and local pressure effects unique to CO2 base minimally invasive surgery alter renal blood flow. We have demonstrated laparoscopic antireflux surgery to have an additional impact upon hemodynamics (decreased cardiac output), potentially extending known effects upon renal blood flow. Methods: We measured renal blood flow with radioactive microspheres during laparoscopic antireflux surgery in a porcine model. Six pigs were anesthetized, monitoring lines were placed, and microspheres injected five time points associated with a laparoscopic antireflux operation. After euthanasia kidneys were retrieved and fixed, and representative samples counted for radioactivity specific for each of the five time points. Results: The greatest reduction in renal blood flow was 36% below baseline (p<0.05). Concurrently, cardiac output had a maximum reduction of 39%. Conclusions: Laparoscopic Nissen fundoplication in this pig model is associated with a significant reduction in renal blood flow, probably related to reduction in cardiac output. Caution is warranted when considering laparoscopic antireflux surgery in patients with a compromised renal blood flow.
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U2 - 10.1016/S0002-9610(02)00824-3
DO - 10.1016/S0002-9610(02)00824-3
M3 - Article
C2 - 11975930
AN - SCOPUS:0036228468
SN - 0002-9610
VL - 183
SP - 419
EP - 423
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 4
ER -