Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention: The PACIFY randomized clinical trial (platelet aggregation with ticagrelor inhibition and fentanyl)

John W. McEvoy; Khalil Ibrahim; Thomas S. Kickler; William A. Clarke; Rani K. Hasan; Matthew J. Czarny; Ali R. Keramati; Rakesh R. Goli; Travis P. Gratton; Jeffrey A. Brinker; Matthews Chacko; Chao Wei Hwang; Peter V. Johnston; Julie M. Miller; Jeffrey C. Trost; William R. Herzog; Roger S. Blumenthal; David R. Thiemann; Jon R. Resar; Steven P. Schulman

doi:10.1161/CIRCULATIONAHA.117.031678

Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention: The PACIFY randomized clinical trial (platelet aggregation with ticagrelor inhibition and fentanyl)

John W. McEvoy, Khalil Ibrahim, Thomas S. Kickler, William A. Clarke, Rani K. Hasan, Matthew J. Czarny, Ali R. Keramati, Rakesh R. Goli, Travis P. Gratton, Jeffrey A. Brinker, Matthews Chacko, Chao Wei Hwang, Peter V. Johnston, Julie M. Miller, Jeffrey C. Trost, William R. Herzog, Roger S. Blumenthal, David R. Thiemann, Jon R. Resar, Steven P. Schulman

Research output: Contribution to journal › Letter › peer-review

34 Scopus citations

Original language	English (US)
Pages (from-to)	307-309
Number of pages	3
Journal	Circulation
Volume	137
Issue number	3
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.117.031678
State	Published - 2018

Keywords

Blood platelets
Fentanyl
Percutaneous coronary intervention
Ticagrelor

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1161/CIRCULATIONAHA.117.031678

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McEvoy, J. W., Ibrahim, K., Kickler, T. S., Clarke, W. A., Hasan, R. K., Czarny, M. J., Keramati, A. R., Goli, R. R., Gratton, T. P., Brinker, J. A., Chacko, M., Hwang, C. W., Johnston, P. V., Miller, J. M., Trost, J. C., Herzog, W. R., Blumenthal, R. S., Thiemann, D. R., Resar, J. R., & Schulman, S. P. (2018). Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention: The PACIFY randomized clinical trial (platelet aggregation with ticagrelor inhibition and fentanyl). Circulation, 137(3), 307-309. https://doi.org/10.1161/CIRCULATIONAHA.117.031678

Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention: The PACIFY randomized clinical trial (platelet aggregation with ticagrelor inhibition and fentanyl). / McEvoy, John W.; Ibrahim, Khalil; Kickler, Thomas S. et al.
In: Circulation, Vol. 137, No. 3, 2018, p. 307-309.

Research output: Contribution to journal › Letter › peer-review

McEvoy, JW, Ibrahim, K, Kickler, TS , Clarke, WA , Hasan, RK , Czarny, MJ, Keramati, AR, Goli, RR, Gratton, TP, Brinker, JA, Chacko, M, Hwang, CW , Johnston, PV , Miller, JM , Trost, JC, Herzog, WR, Blumenthal, RS , Thiemann, DR , Resar, JR & Schulman, SP 2018, 'Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention: The PACIFY randomized clinical trial (platelet aggregation with ticagrelor inhibition and fentanyl)', Circulation, vol. 137, no. 3, pp. 307-309. https://doi.org/10.1161/CIRCULATIONAHA.117.031678

McEvoy JW, Ibrahim K, Kickler TS , Clarke WA , Hasan RK , Czarny MJ et al. Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention: The PACIFY randomized clinical trial (platelet aggregation with ticagrelor inhibition and fentanyl). Circulation. 2018;137(3):307-309. doi: 10.1161/CIRCULATIONAHA.117.031678

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title = "Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention: The PACIFY randomized clinical trial (platelet aggregation with ticagrelor inhibition and fentanyl)",

keywords = "Blood platelets, Fentanyl, Percutaneous coronary intervention, Ticagrelor",

author = "McEvoy, {John W.} and Khalil Ibrahim and Kickler, {Thomas S.} and Clarke, {William A.} and Hasan, {Rani K.} and Czarny, {Matthew J.} and Keramati, {Ali R.} and Goli, {Rakesh R.} and Gratton, {Travis P.} and Brinker, {Jeffrey A.} and Matthews Chacko and Hwang, {Chao Wei} and Johnston, {Peter V.} and Miller, {Julie M.} and Trost, {Jeffrey C.} and Herzog, {William R.} and Blumenthal, {Roger S.} and Thiemann, {David R.} and Resar, {Jon R.} and Schulman, {Steven P.}",

note = "Funding Information: PACIFY was fully funded by an institutional grant awarded to Dr McEvoy from the Johns Hopkins Magic That Matters Research Fund. Funding Information: Ciccarone Center for the Prevention of Heart Disease (J.W.M., R.S.B.), Division of Cardiology, Department of Medicine (J.W.M., K.I., R.K.H., M.J.C., A.R.K., J.A.B., M.C., C.-W.H., P.V.J., J.M.M., J.C.T., W.R.H., R.S.B., D.R.T., J.R.R., S.P.S.), Department of Pathology (T.S.K., W.A.C.), Department of Medicine (R.R.G., T.P.G.), Johns Hopkins University School of Medicine, Baltimore, MD. Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (J.W.M.).",

year = "2018",

doi = "10.1161/CIRCULATIONAHA.117.031678",

language = "English (US)",

volume = "137",

pages = "307--309",

journal = "Circulation",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention

T2 - The PACIFY randomized clinical trial (platelet aggregation with ticagrelor inhibition and fentanyl)

AU - McEvoy, John W.

AU - Ibrahim, Khalil

AU - Kickler, Thomas S.

AU - Clarke, William A.

AU - Hasan, Rani K.

AU - Czarny, Matthew J.

AU - Keramati, Ali R.

AU - Goli, Rakesh R.

AU - Gratton, Travis P.

AU - Brinker, Jeffrey A.

AU - Chacko, Matthews

AU - Hwang, Chao Wei

AU - Johnston, Peter V.

AU - Miller, Julie M.

AU - Trost, Jeffrey C.

AU - Herzog, William R.

AU - Blumenthal, Roger S.

AU - Thiemann, David R.

AU - Resar, Jon R.

AU - Schulman, Steven P.

N1 - Funding Information: PACIFY was fully funded by an institutional grant awarded to Dr McEvoy from the Johns Hopkins Magic That Matters Research Fund. Funding Information: Ciccarone Center for the Prevention of Heart Disease (J.W.M., R.S.B.), Division of Cardiology, Department of Medicine (J.W.M., K.I., R.K.H., M.J.C., A.R.K., J.A.B., M.C., C.-W.H., P.V.J., J.M.M., J.C.T., W.R.H., R.S.B., D.R.T., J.R.R., S.P.S.), Department of Pathology (T.S.K., W.A.C.), Department of Medicine (R.R.G., T.P.G.), Johns Hopkins University School of Medicine, Baltimore, MD. Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (J.W.M.).

PY - 2018

Y1 - 2018

KW - Blood platelets

KW - Fentanyl

KW - Percutaneous coronary intervention

KW - Ticagrelor

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U2 - 10.1161/CIRCULATIONAHA.117.031678

DO - 10.1161/CIRCULATIONAHA.117.031678

M3 - Letter

C2 - 29046319

AN - SCOPUS:85044031691

SN - 0009-7322

VL - 137

SP - 307

EP - 309

JO - Circulation

JF - Circulation

IS - 3

ER -

Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention: The PACIFY randomized clinical trial (platelet aggregation with ticagrelor inhibition and fentanyl)

Keywords

ASJC Scopus subject areas

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