Effect of intellectual enrichment on AD biomarker trajectories

Prashanthi Vemuri; Timothy G. Lesnick; Scott A. Przybelski; David S. Knopman; Mary Machulda; Val J. Lowe; Michelle M. Mielke; Rosebud O. Roberts; Jeffrey L. Gunter; Matthew L. Senjem; Yonas E. Geda; Walter A. Rocca; Ronald C. Petersen; Clifford R. Jack

doi:10.1212/WNL.0000000000002490

Effect of intellectual enrichment on AD biomarker trajectories

Prashanthi Vemuri, Timothy G. Lesnick, Scott A. Przybelski, David S. Knopman, Mary Machulda, Val J. Lowe, Michelle M. Mielke, Rosebud O. Roberts, Jeffrey L. Gunter, Matthew L. Senjem, Yonas E. Geda, Walter A. Rocca, Ronald C. Petersen, Clifford R. Jack

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Objective: To investigate the effect of age, sex, APOE4 genotype, and lifestyle enrichment (education/occupation, midlife cognitive activity, and midlife physical activity) on Alzheimer disease (AD) biomarker trajectories using longitudinal imaging data (brain β-amyloid load via Pittsburgh compound B PET and neurodegeneration via 18 fluorodeoxyglucose (FDG) PET and structural MRI) in an elderly population without dementia. Methods: In the population-based longitudinal Mayo Clinic Study of Aging, we studied 393 participants without dementia (340 clinically normal, 53 mild cognitive impairment; 70 years and older) who had cognitive and physical activity measures and at least 2 visits with imaging biomarkers. We dichotomized participants into high (≥14 years) and low (

Original language	English (US)
Pages (from-to)	1128-1135
Number of pages	8
Journal	Neurology
Volume	86
Issue number	12
DOIs	https://doi.org/10.1212/WNL.0000000000002490
State	Published - Mar 22 2016
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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10.1212/WNL.0000000000002490

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title = "Effect of intellectual enrichment on AD biomarker trajectories",

abstract = "Objective: To investigate the effect of age, sex, APOE4 genotype, and lifestyle enrichment (education/occupation, midlife cognitive activity, and midlife physical activity) on Alzheimer disease (AD) biomarker trajectories using longitudinal imaging data (brain β-amyloid load via Pittsburgh compound B PET and neurodegeneration via 18 fluorodeoxyglucose (FDG) PET and structural MRI) in an elderly population without dementia. Methods: In the population-based longitudinal Mayo Clinic Study of Aging, we studied 393 participants without dementia (340 clinically normal, 53 mild cognitive impairment; 70 years and older) who had cognitive and physical activity measures and at least 2 visits with imaging biomarkers. We dichotomized participants into high (≥14 years) and low (",

author = "Prashanthi Vemuri and Lesnick, {Timothy G.} and Przybelski, {Scott A.} and Knopman, {David S.} and Mary Machulda and Lowe, {Val J.} and Mielke, {Michelle M.} and Roberts, {Rosebud O.} and Gunter, {Jeffrey L.} and Senjem, {Matthew L.} and Geda, {Yonas E.} and Rocca, {Walter A.} and Petersen, {Ronald C.} and Jack, {Clifford R.}",

year = "2016",

month = mar,

day = "22",

doi = "10.1212/WNL.0000000000002490",

language = "English (US)",

volume = "86",

pages = "1128--1135",

journal = "Neurology",

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publisher = "Lippincott Williams and Wilkins",

number = "12",

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TY - JOUR

T1 - Effect of intellectual enrichment on AD biomarker trajectories

AU - Vemuri, Prashanthi

AU - Lesnick, Timothy G.

AU - Przybelski, Scott A.

AU - Knopman, David S.

AU - Machulda, Mary

AU - Lowe, Val J.

AU - Mielke, Michelle M.

AU - Roberts, Rosebud O.

AU - Gunter, Jeffrey L.

AU - Senjem, Matthew L.

AU - Geda, Yonas E.

AU - Rocca, Walter A.

AU - Petersen, Ronald C.

AU - Jack, Clifford R.

PY - 2016/3/22

Y1 - 2016/3/22

N2 - Objective: To investigate the effect of age, sex, APOE4 genotype, and lifestyle enrichment (education/occupation, midlife cognitive activity, and midlife physical activity) on Alzheimer disease (AD) biomarker trajectories using longitudinal imaging data (brain β-amyloid load via Pittsburgh compound B PET and neurodegeneration via 18 fluorodeoxyglucose (FDG) PET and structural MRI) in an elderly population without dementia. Methods: In the population-based longitudinal Mayo Clinic Study of Aging, we studied 393 participants without dementia (340 clinically normal, 53 mild cognitive impairment; 70 years and older) who had cognitive and physical activity measures and at least 2 visits with imaging biomarkers. We dichotomized participants into high (≥14 years) and low (

AB - Objective: To investigate the effect of age, sex, APOE4 genotype, and lifestyle enrichment (education/occupation, midlife cognitive activity, and midlife physical activity) on Alzheimer disease (AD) biomarker trajectories using longitudinal imaging data (brain β-amyloid load via Pittsburgh compound B PET and neurodegeneration via 18 fluorodeoxyglucose (FDG) PET and structural MRI) in an elderly population without dementia. Methods: In the population-based longitudinal Mayo Clinic Study of Aging, we studied 393 participants without dementia (340 clinically normal, 53 mild cognitive impairment; 70 years and older) who had cognitive and physical activity measures and at least 2 visits with imaging biomarkers. We dichotomized participants into high (≥14 years) and low (

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Effect of intellectual enrichment on AD biomarker trajectories

Abstract

ASJC Scopus subject areas

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