The effect of increasing age on the ability to metabolize thyroxine by rat liver homogenate was studied. Rats aged 6 weeks (young), 6 months (mature), and 20 months (senescent) showed no difference in the ability to deiodinate thyroxine at the 51-position to form T3. There was, however, an age related decrease in the ability to generate excess iodide, implying less degradation through the 5-monodeiodinase pathway.
ASJC Scopus subject areas
- Geriatrics and Gerontology