Effect of increasing age on the degradation of thyroxine by rat liver homogenate

Steven R. Gambert

doi:10.1007/BF02431983

Effect of increasing age on the degradation of thyroxine by rat liver homogenate

Steven R. Gambert

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The effect of increasing age on the ability to metabolize thyroxine by rat liver homogenate was studied. Rats aged 6 weeks (young), 6 months (mature), and 20 months (senescent) showed no difference in the ability to deiodinate thyroxine at the 5¹-position to form T₃. There was, however, an age related decrease in the ability to generate excess iodide, implying less degradation through the 5-monodeiodinase pathway.

Original language	English (US)
Pages (from-to)	48-50
Number of pages	3
Journal	AGE
Volume	4
Issue number	2
DOIs	https://doi.org/10.1007/BF02431983
State	Published - Apr 1 1981

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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10.1007/BF02431983

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abstract = "The effect of increasing age on the ability to metabolize thyroxine by rat liver homogenate was studied. Rats aged 6 weeks (young), 6 months (mature), and 20 months (senescent) showed no difference in the ability to deiodinate thyroxine at the 51-position to form T3. There was, however, an age related decrease in the ability to generate excess iodide, implying less degradation through the 5-monodeiodinase pathway.",

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Effect of increasing age on the degradation of thyroxine by rat liver homogenate

Abstract

ASJC Scopus subject areas

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