Effect of hypothermia on the thalamocortical function in the rat model.

Anil Maybhate, Cheng Chen, Nitish V. Thakor, Xiaofeng Jia

Research output: Contribution to journalArticlepeer-review


Neuroprotective effects of hypothermia are well documented in many injuries of the central nervous system in animal models as well as clinical studies. However, the underlying mechanisms are not fully understood. An important yet unexplored background issue is the effect of hypothermic cooling on the regional functionality of the healthy CNS. In a pilot study with the rat model, we seek to characterize the effect of moderate bodily cooling on the thalamo-cortical (T-C) function. Multiunit activity (MUA) and local field potentials (LFPs) were recorded from the thalamus (VPL nucleus) and the somatosensory cortex (S1) for normothermic, mild hypothermic and mild hyperthermic conditions in healthy rats and the thalamo-cortical dynamics was characterized with Granger Causal Interaction (GCI). The GCI indicated that the thalamic driving of the cortical activity significantly increases in strength with bodily cooling and weakens with mild heating. These results could have important implications towards understanding of hypothermia.

Original languageEnglish (US)
Pages (from-to)4680-4683
Number of pages4
JournalConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
StatePublished - 2012
Externally publishedYes

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics


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