TY - JOUR
T1 - Effect of HIV-infection and cumulative viral load on age-related decline in grip strength
AU - Schrack, Jennifer A.
AU - Jacobson, Lisa P.
AU - Althoff, Keri N.
AU - Erlandson, Kristine M.
AU - Jamieson, Beth D.
AU - Koletar, Susan L.
AU - Phair, John
AU - Brown, Todd T.
AU - Margolick, Joseph B.
N1 - Funding Information:
The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). J.A.S. was supported by K01AG048765 from NIA. K.N.A. was supported by K01AI093197 from NIAID. K.M.E. was support by K23AG050260 from NIA. T.T.B. was supported in part by R01AI093520 and K24AI120834 from the NIAID. This work was also supported by the JHU CFAR (1P30AI094189).
Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc.
PY - 2016/11/13
Y1 - 2016/11/13
N2 - Objective: Grip strength predicts functional decline and death, and is regarded as a biomarker of biological aging. The primary objective of this manuscript was to assess differences in the rate of decline in grip strength in persons aging with and without HIV. Design: Grip strength was assessed in 1552 (716 HIV+ and 836 HIV-) men aged at least 50 years participating in the Multicenter AIDS Cohort Study between 2007 and 2014. Methods: Grip strength decline was modeled longitudinally, adjusting for serostatus, demographics, comorbidities, and conditions. In HIV-specific models, coefficients were included for cumulative viral load and history of AIDS. Results: Grip strength at the age of 50 years averaged 37.9 and 38.2 kg for HIV+ and HIV- men, respectively (P=0.70). In fully adjusted models, grip strength declined 0.33 kg/year in HIV- men (P<0.001) and 0.42 kg/year in HIV+ men (P=0.01). In HIVstratified models, higher cumulative viral load indicated greater strength decline (-0.884 kg for 3.1-4.0 log10 copies-years/ml and -1.077 kg for ≥4.1 log10 copiesyears/ ml) relative to men with consistently low viral load (≤3.0 log10 copies-years/ml). Adjusted Cox proportional hazard models revealed a 70% greater risk of clinically weak grip strength in HIV+ men (adjusted hazard ratio 1.70; 95% confidence interval, 1.22- 2.40). Conclusion: Grip strength decline is accelerated in HIV-infected men, which may contribute to decreased life expectancy and lower quality of life with aging. Greater cumulative viral load exposure appears to be an important driver of this decline and underscores the importance of early initiation of therapy.
AB - Objective: Grip strength predicts functional decline and death, and is regarded as a biomarker of biological aging. The primary objective of this manuscript was to assess differences in the rate of decline in grip strength in persons aging with and without HIV. Design: Grip strength was assessed in 1552 (716 HIV+ and 836 HIV-) men aged at least 50 years participating in the Multicenter AIDS Cohort Study between 2007 and 2014. Methods: Grip strength decline was modeled longitudinally, adjusting for serostatus, demographics, comorbidities, and conditions. In HIV-specific models, coefficients were included for cumulative viral load and history of AIDS. Results: Grip strength at the age of 50 years averaged 37.9 and 38.2 kg for HIV+ and HIV- men, respectively (P=0.70). In fully adjusted models, grip strength declined 0.33 kg/year in HIV- men (P<0.001) and 0.42 kg/year in HIV+ men (P=0.01). In HIVstratified models, higher cumulative viral load indicated greater strength decline (-0.884 kg for 3.1-4.0 log10 copies-years/ml and -1.077 kg for ≥4.1 log10 copiesyears/ ml) relative to men with consistently low viral load (≤3.0 log10 copies-years/ml). Adjusted Cox proportional hazard models revealed a 70% greater risk of clinically weak grip strength in HIV+ men (adjusted hazard ratio 1.70; 95% confidence interval, 1.22- 2.40). Conclusion: Grip strength decline is accelerated in HIV-infected men, which may contribute to decreased life expectancy and lower quality of life with aging. Greater cumulative viral load exposure appears to be an important driver of this decline and underscores the importance of early initiation of therapy.
KW - Aging
KW - Clinical weakness
KW - Cumulative viral load
KW - Functional decline
KW - Grip strength
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U2 - 10.1097/QAD.0000000000001245
DO - 10.1097/QAD.0000000000001245
M3 - Article
C2 - 27603294
AN - SCOPUS:84986203575
SN - 0269-9370
VL - 30
SP - 2645
EP - 2652
JO - AIDS
JF - AIDS
IS - 17
ER -