Effect of food intake on the metabolic clearance rate of aldosterone

A. Akesode, C. J. Migeon, A. A. Kowarski

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The effect of eating on the metabolic clearance rate (MCR) of aldosterone was investigated in 10 adult individuals,3H-aldosterone was infused continuously over a period of 5 h while the subjects remained supine. Three h after the start of the infusion, each subject ate a bowl of soup. The MCR of aldosterone, before and after the intake of food, was calculated by dividing the rate of infusion of3H-aldosterone by the mean concentration of 3H-aldosterone during these two periods. The MCR of 11 subjects was measured under the same conditions but without eating. The MCR of aldosterone (mean + 1 SD) was 1284 + 513 L/24 h before food intake and 2182 + 180 L/24 h after food intake in the 10 individuals who ate. The MCR in the 11 subjects who did not eat was 1363 + 446 and 1357 + 434 during the same periods (p>0.05). The 29% increase in the MCR induced by eating was highly significant (p< 0.001); it was similar in magnitude and duration to a previously reported effect of food intake on the hepatic blood flow (13).

Original languageEnglish (US)
Pages (from-to)849-852
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
StatePublished - Oct 1977
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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