Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates

Katherine E. Warren; Cynthia M. McCully; Thomas J. Walsh; Frank M. Balis

doi:10.1128/AAC.44.4.1100-1101.2000

Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates

Katherine E. Warren, Cynthia M. McCully, Thomas J. Walsh, Frank M. Balis

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Antifungal prophylaxis in cancer patients who are undergoing chemotherapy is associated with prolonged neutropenia. We measured the effect of fluconazole on doxorubicin pharmacokinetics in nonhuman primates to determine if neutropenia is related to a pharmacokinetic interaction that delays the clearance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.

Original language	English (US)
Pages (from-to)	1100-1101
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	44
Issue number	4
DOIs	https://doi.org/10.1128/AAC.44.4.1100-1101.2000
State	Published - Apr 2000
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.44.4.1100-1101.2000

Cite this

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title = "Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates",

abstract = "Antifungal prophylaxis in cancer patients who are undergoing chemotherapy is associated with prolonged neutropenia. We measured the effect of fluconazole on doxorubicin pharmacokinetics in nonhuman primates to determine if neutropenia is related to a pharmacokinetic interaction that delays the clearance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.",

author = "Warren, {Katherine E.} and McCully, {Cynthia M.} and Walsh, {Thomas J.} and Balis, {Frank M.}",

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AB - Antifungal prophylaxis in cancer patients who are undergoing chemotherapy is associated with prolonged neutropenia. We measured the effect of fluconazole on doxorubicin pharmacokinetics in nonhuman primates to determine if neutropenia is related to a pharmacokinetic interaction that delays the clearance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.

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Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates

Abstract

ASJC Scopus subject areas

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