TY - JOUR
T1 - Effect of daily fiber intake on luteinizing hormone levels in reproductive-aged women
AU - Gaskins, Audrey J.
AU - Mumford, Sunni L.
AU - Wactawski-Wende, Jean
AU - Schisterman, Enrique F.
N1 - Funding Information:
Acknowledgments Funding: The BioCycle study and their researchers were supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Contributors: The authors thank all the investigators and staff at the University at Buffalo and NICHD for their respective roles in the study, specifically Cuilin Zhang, Kathleen M. Hovey, Brian W. Whitcomb, Penelope P. Howards, Neil J. Perkins, and Edwina Yeung.
PY - 2012/3
Y1 - 2012/3
N2 - Purpose: To evaluate whether the association between fiber intake and LH levels is driven by the association between fiber and estradiol, or whether there is an independent association. Methods: A prospective cohort of 259 premenopausal women were followed for up to 2 menstrual cycles. Estrogen and LH were measured ≤8 times per cycle at visits scheduled using fertility monitors. Diet was assessed ≤4 times per cycle by 24-h recall. Linear mixed models on the log scale of hormones were utilized to evaluate the total effects of fiber intake. Inverse probability weights were utilized to estimate the independent effect of fiber on LH levels. Results: In unweighted analyses, we observed a significant, inverse association between fiber intake (in 5 g/day increments) and log LH levels (β, -0.051, 95% confidence interval (CI), -0.100, -0.002). No association was observed in the weighted analyses, after estradiol levels were taken into account (β, -0.016, 95% CI, -0.060, 0.027). Conclusions: The decreased levels of LH associated with high fiber intake were attenuated after taking estradiol levels into account, suggesting that the association between fiber and LH is most likely a consequence of fiber's impact on estradiol and not due to an independent mechanism.
AB - Purpose: To evaluate whether the association between fiber intake and LH levels is driven by the association between fiber and estradiol, or whether there is an independent association. Methods: A prospective cohort of 259 premenopausal women were followed for up to 2 menstrual cycles. Estrogen and LH were measured ≤8 times per cycle at visits scheduled using fertility monitors. Diet was assessed ≤4 times per cycle by 24-h recall. Linear mixed models on the log scale of hormones were utilized to evaluate the total effects of fiber intake. Inverse probability weights were utilized to estimate the independent effect of fiber on LH levels. Results: In unweighted analyses, we observed a significant, inverse association between fiber intake (in 5 g/day increments) and log LH levels (β, -0.051, 95% confidence interval (CI), -0.100, -0.002). No association was observed in the weighted analyses, after estradiol levels were taken into account (β, -0.016, 95% CI, -0.060, 0.027). Conclusions: The decreased levels of LH associated with high fiber intake were attenuated after taking estradiol levels into account, suggesting that the association between fiber and LH is most likely a consequence of fiber's impact on estradiol and not due to an independent mechanism.
KW - Dietary fiber
KW - Estradiol
KW - Luteinizing hormone
KW - Women
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U2 - 10.1007/s00394-011-0207-2
DO - 10.1007/s00394-011-0207-2
M3 - Article
C2 - 21667182
AN - SCOPUS:84860662890
SN - 1436-6207
VL - 51
SP - 249
EP - 253
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 2
ER -