Cyproheptadine, an antagonist of histamine and serotonin, was compared with chlorpheniramine in a double blind study of 28 asthmatic children. Patients receiving cyproheptadine showed a marked increase in appetite, an associated weight gain, and an accelerated linear growth rate. The weight gain was apparently a reflection of simple exogenous obesity; there was no evidence of fluid retention. These effects of cyproheptadine could not be ascribed to a superior antihistaminic or antiasthmatic activity of the compound, since cyproheptadine and chlorpheniramine appeared equal in these respects.
|Original language||English (US)|
|Number of pages||5|
|Journal||JAMA: The Journal of the American Medical Association|
|State||Published - Jun 16 1962|
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