Effect of carbamazepine on CSF opioid activity: Relationship to antidepressant response

Robert M. Post, David Pickar, Dieter Naber, James C. Ballenger, Thomas W. Uhde, William E. Bunney

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Carbamazepine, a drug useful in the treatment of trigeminal neuralgia and temporal lobe epilepsy, has recently been found to have positive psychotropic effects in patients with manic and depressive illness. The possible effects of carbamazepine on opioid activity in cerebrospinal fluid (CSF) were assessed in patients with affective disorders using a radioreceptor assay that detects total opioid binding activity. No effect of carbamazepine was noted on CSF total opioid activity, although conclusions about its possible effects on discrete opiate systems must await other methodologies. Initial medication-free levels of opioid activity were positively correlated with the degree of antidepressant response to carbamazepine.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalPsychiatry Research
Issue number1
StatePublished - 1981
Externally publishedYes


  • beta-endorphin
  • Carbamazepine
  • cerebrospinal fluid
  • depression
  • mania
  • opiates

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)


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