Effect of anterior-posterior lesion location on the asymmetrical behavioral and biochemical response to cortical suction ablations in the rat

Godfrey D. Pearlson; Kenneth L. Kubos; Robert G. Robinson

doi:10.1016/0006-8993(84)91231-9

Effect of anterior-posterior lesion location on the asymmetrical behavioral and biochemical response to cortical suction ablations in the rat

Godfrey D. Pearlson, Kenneth L. Kubos, Robert G. Robinson

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Small cortical suction ablations were produced at one of several stereotaxically located sites along the anterior-posterior axis of the right or left hemisphere in the rat. Analysis of variance showed a highly significant effect of lesion location in the right hemisphere on locomotor activity. The most anterior lesions produced both the most hyperactivity and also the greatest reductions in the concentrations of noripinephrine in the ipsilateral and contralateral cortex and locus coeruleus. These results suggest that the effect of cortical lesions on spontaneous activity may be graded across the right hemisphere and that the anatomy of certain neurotransmitter pathways in the cortex may help to explain both the biochemical and behavioral findings.

Original language	English (US)
Pages (from-to)	241-250
Number of pages	10
Journal	Brain research
Volume	293
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)91231-9
State	Published - Feb 20 1984

Keywords

asymmetrical behavior
cortical lesions

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)91231-9

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abstract = "Small cortical suction ablations were produced at one of several stereotaxically located sites along the anterior-posterior axis of the right or left hemisphere in the rat. Analysis of variance showed a highly significant effect of lesion location in the right hemisphere on locomotor activity. The most anterior lesions produced both the most hyperactivity and also the greatest reductions in the concentrations of noripinephrine in the ipsilateral and contralateral cortex and locus coeruleus. These results suggest that the effect of cortical lesions on spontaneous activity may be graded across the right hemisphere and that the anatomy of certain neurotransmitter pathways in the cortex may help to explain both the biochemical and behavioral findings.",

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AB - Small cortical suction ablations were produced at one of several stereotaxically located sites along the anterior-posterior axis of the right or left hemisphere in the rat. Analysis of variance showed a highly significant effect of lesion location in the right hemisphere on locomotor activity. The most anterior lesions produced both the most hyperactivity and also the greatest reductions in the concentrations of noripinephrine in the ipsilateral and contralateral cortex and locus coeruleus. These results suggest that the effect of cortical lesions on spontaneous activity may be graded across the right hemisphere and that the anatomy of certain neurotransmitter pathways in the cortex may help to explain both the biochemical and behavioral findings.

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Effect of anterior-posterior lesion location on the asymmetrical behavioral and biochemical response to cortical suction ablations in the rat

Abstract

Keywords

ASJC Scopus subject areas

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