Effect of anovulatory drugs on the human urinary tract and urinary tract infections

Forty-four women using either Demulen, Dela-droxate, or an intrauterine device for contraceptive purposes were studied for urinary tract disorders. Excretory urograms and serum creatinines were performed before contraception was initiated and thereafter at six-cycle intervals. Monthly urine specimens were cultured and examined cytologically. No effect on the urinary tract was noted by X-ray studies and the creatinines all remained normal. Cytologic studies also revealed no abnormalities. The incidence of positive urine cultures was 6.8% initially and 11% during the course of study. Only one woman developed symptoms of infection. A review of the urograms of patients followed in the Family Planning Clinic indicated that dilatation of the upper urinary tract cannot be attributed to anovulatory drugs.