Abstract
A palladium catalyzed route for the preparation of several benzofuran analogues of the PKC activator indolactam V (ILV) is described together with the ability of these compounds to activate the isoforms of PKC. The benzofuran analogues of ILV are shown to activate PKC with a slightly different pattern of isotype selectivity than ILV or 7-n-octyl-ILV. Moreover, in an examination of the effect of stereochemistry at the C-14 center of the teleocidins on PKC binding activity, a clear preference for R-stereochemistry at the C-14 center was found, thus providing additional verification of previously published structural correlations between the families of PKC activators.
Original language | English (US) |
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Pages (from-to) | 425-430 |
Number of pages | 6 |
Journal | Farmaco |
Volume | 50 |
Issue number | 6 |
State | Published - Jan 1 1995 |
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery