Effect of age on plasma 1,25-(OH)2 vitamin D in the rat

Richard W. Gray; Steven R. Gambert

doi:10.1007/BF02431725

Effect of age on plasma 1,25-(OH)₂ vitamin D in the rat

Richard W. Gray, Steven R. Gambert

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Levels of plasma calcium, phosphorus, creatinine and 1,25-(OH)₂-D were measured in healthy male Sprague-Dawley rats aged 6 months (mature) and 20-24 months (senescent). Plasma 1,25-(OH)₂-D levels fell from 95 ± 50 pmol/l in the mature rats to 41 ± 10 pmol/l in the senescent rats (p < 0.01). Despite a significant fall in plasma phosphate from 3.06 ± 0.37 mmol/l to 2.54 mmol/l (p < 0.005) in the two groups, respectively, plasma calcium remained constant at about 2.4 mmol/l in both groups.

Original language	English (US)
Pages (from-to)	54-56
Number of pages	3
Journal	AGE
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/BF02431725
State	Published - Apr 1982
Externally published	Yes

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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10.1007/BF02431725

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title = "Effect of age on plasma 1,25-(OH)2 vitamin D in the rat",

abstract = "Levels of plasma calcium, phosphorus, creatinine and 1,25-(OH)2-D were measured in healthy male Sprague-Dawley rats aged 6 months (mature) and 20-24 months (senescent). Plasma 1,25-(OH)2-D levels fell from 95 ± 50 pmol/l in the mature rats to 41 ± 10 pmol/l in the senescent rats (p < 0.01). Despite a significant fall in plasma phosphate from 3.06 ± 0.37 mmol/l to 2.54 mmol/l (p < 0.005) in the two groups, respectively, plasma calcium remained constant at about 2.4 mmol/l in both groups.",

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AU - Gray, Richard W.

AU - Gambert, Steven R.

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N2 - Levels of plasma calcium, phosphorus, creatinine and 1,25-(OH)2-D were measured in healthy male Sprague-Dawley rats aged 6 months (mature) and 20-24 months (senescent). Plasma 1,25-(OH)2-D levels fell from 95 ± 50 pmol/l in the mature rats to 41 ± 10 pmol/l in the senescent rats (p < 0.01). Despite a significant fall in plasma phosphate from 3.06 ± 0.37 mmol/l to 2.54 mmol/l (p < 0.005) in the two groups, respectively, plasma calcium remained constant at about 2.4 mmol/l in both groups.

AB - Levels of plasma calcium, phosphorus, creatinine and 1,25-(OH)2-D were measured in healthy male Sprague-Dawley rats aged 6 months (mature) and 20-24 months (senescent). Plasma 1,25-(OH)2-D levels fell from 95 ± 50 pmol/l in the mature rats to 41 ± 10 pmol/l in the senescent rats (p < 0.01). Despite a significant fall in plasma phosphate from 3.06 ± 0.37 mmol/l to 2.54 mmol/l (p < 0.005) in the two groups, respectively, plasma calcium remained constant at about 2.4 mmol/l in both groups.

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Effect of age on plasma 1,25-(OH)₂ vitamin D in the rat

Abstract

ASJC Scopus subject areas

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