TY - JOUR
T1 - Effect of acidosis on heart camp-dependent protein kinase
AU - Chiappe De Mon, Liliana E.
AU - Chiappe De Cingolani, Gladys E.
AU - Cingolani, H. E.
N1 - Funding Information:
(l) Established Investigators from the Consejo Nacional de Investigaciones Cientifi-cas y Ticnicas, Argentina. (z)T his work was supported by a grant from the Consejo Nacional de Investiga-ciones Cientifcas y Ticnicas, Argentina.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1978
Y1 - 1978
N2 - The effect of acidosis on cAMP-dependent protein kinase activity in perfused hearts from normal and reserpinized rats has been investigated. The results were compared to the effect of acidosis on myocardial contractility under the same conditions. The results showed that acidosis increases the cAMP-dependent protein kinase activity in normal hearts. This increase was abolished when the hearts were depleted of norepinephrine by previous treatment with reserpine. As regards myocardial contractility, there was a similar decrease by acidosis either in normal hearts with increased cAMP-dependent protein kinase activity or in reserpinized hearts in which the increase in protein kinase activity was prevented. Two alternative hypotheses are suggested : (1) a dissociation between contractility and cAMP levels, or (2) a "blockade" by acidosis of the mechanical effect of increasing cAMP-dependent protein kinase activity.
AB - The effect of acidosis on cAMP-dependent protein kinase activity in perfused hearts from normal and reserpinized rats has been investigated. The results were compared to the effect of acidosis on myocardial contractility under the same conditions. The results showed that acidosis increases the cAMP-dependent protein kinase activity in normal hearts. This increase was abolished when the hearts were depleted of norepinephrine by previous treatment with reserpine. As regards myocardial contractility, there was a similar decrease by acidosis either in normal hearts with increased cAMP-dependent protein kinase activity or in reserpinized hearts in which the increase in protein kinase activity was prevented. Two alternative hypotheses are suggested : (1) a dissociation between contractility and cAMP levels, or (2) a "blockade" by acidosis of the mechanical effect of increasing cAMP-dependent protein kinase activity.
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U2 - 10.3109/13813457809069905
DO - 10.3109/13813457809069905
M3 - Article
C2 - 80985
AN - SCOPUS:0017899934
SN - 1381-3455
VL - 86
SP - 277
EP - 287
JO - Archives of Physiology and Biochemistry
JF - Archives of Physiology and Biochemistry
IS - 2
ER -