Effect of a selective COX-2 inhibitor, celecoxib, on heterotopic ossification after total hip arthroplasty: A case-controlled study

Julius K. Oni; Joseph R. Pinero; Bryan M. Saltzman; Fredrick F. Jaffe

doi:10.5301/hipint.5000109

Effect of a selective COX-2 inhibitor, celecoxib, on heterotopic ossification after total hip arthroplasty: A case-controlled study

Julius K. Oni, Joseph R. Pinero, Bryan M. Saltzman, Fredrick F. Jaffe

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Heterotopic ossification (HO) is a well-known complication of total hip arthroplasty (THA), especially when the direct lateral approach is used. In this study, we examined the effect of the selective COX-2 inhibitor, celecoxib, on the rates of HO after THA. A control group consisting of 108 patients that did not receive celecoxib was compared with a study group consisting of 106 patients that did receive celecoxib. We assessed the presence and grade of HO using the Brooker classification and Harris hip scores were determined pre-and postoperatively to better quantify clinical outcomes. In this retrospective study of prospectively collected data, celecoxib is associated with a significant reduction in the incidence of HO in patients undergoing THA.

Original language	English (US)
Pages (from-to)	256-262
Number of pages	7
Journal	HIP International
Volume	24
Issue number	3
DOIs	https://doi.org/10.5301/hipint.5000109
State	Published - Jan 1 2014
Externally published	Yes

Keywords

Celecoxib
Cyclooxygenase-2
Heterotopic
Ossification
Postoperative complication
Total hip replacement

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

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10.5301/hipint.5000109

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title = "Effect of a selective COX-2 inhibitor, celecoxib, on heterotopic ossification after total hip arthroplasty: A case-controlled study",

abstract = "Heterotopic ossification (HO) is a well-known complication of total hip arthroplasty (THA), especially when the direct lateral approach is used. In this study, we examined the effect of the selective COX-2 inhibitor, celecoxib, on the rates of HO after THA. A control group consisting of 108 patients that did not receive celecoxib was compared with a study group consisting of 106 patients that did receive celecoxib. We assessed the presence and grade of HO using the Brooker classification and Harris hip scores were determined pre-and postoperatively to better quantify clinical outcomes. In this retrospective study of prospectively collected data, celecoxib is associated with a significant reduction in the incidence of HO in patients undergoing THA.",

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AU - Saltzman, Bryan M.

AU - Jaffe, Fredrick F.

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KW - Ossification

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Effect of a selective COX-2 inhibitor, celecoxib, on heterotopic ossification after total hip arthroplasty: A case-controlled study

Abstract

Keywords

ASJC Scopus subject areas

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