EEG reactivity in neurologic prognostication in post-cardiac arrest patients: A narrative review

Marlen G. Fahrner, Jaeho Hwang, Sung Min Cho, Nitish V. Thakor, Christa W. Habela, Peter W. Kaplan, Romergryko G. Geocadin

Research output: Contribution to journalReview articlepeer-review

Abstract

Electroencephalographic reactivity (EEG-R) is a promising early predictor of arousal in comatose patients after cardiac arrest. Despite recent guidelines advocating for the integration of EEG-R into the multimodal prognostication model, EEG-R testing methods remain heterogeneous across studies. While efforts towards standardization have been made to reduce interrater variability by the development of quantitative approaches and machine learning models, future validation studies are needed to increase clinical applicability. Furthermore, the specific neurophysiological mechanisms and neuroanatomical correlates underlying EEG-R are not fully understood. In this narrative review, we explore the value and possible mechanisms of EEG-R, focusing on post-cardiac arrest comatose patients. We aim to discuss the current standard of knowledge and future directions, as well as elucidate possible implications for patient care and research.

Original languageEnglish (US)
Article number110398
JournalResuscitation
Volume204
DOIs
StatePublished - Nov 2024

Keywords

  • Cardiac arrest
  • Coma
  • EEG
  • Neuroprognostication
  • Reactivity
  • Review

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

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