@article{020f72322e0b4a39afec5f6df3589ca9,
title = "Educational Case: Burkitt Lymphoma",
abstract = "The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.1",
keywords = "Burkitt lymphoma, hematopathology, lymph nodes, lymphoma, organ system pathology, pathology competencies, pediatric, white cell disorders",
author = "Alexander, {Caitlin J.} and Wake, {Laura M.}",
note = "Funding Information: Lymphomas are diagnosed pathologically by morphology, antigen expression as determined by immunophenotype and flow cytometry, and genetics. Burkitt lymphoma has a rapid onset of disease; however, symptoms vary widely based on the location of tumor involvement. There are 3 subtypes of Burkitt lymphoma—endemic, immunodeficiency associated, and sporadic. The sporadic variant is most common in the United States. The histology of Burkitt lymphoma shows sheets of monomorphic medium lymphocytes with a high mitotic rate and frequent apoptotic bodies, classically described as a “starry-sky” appearance. Translocation of the MYC gene, typically t(8;14), is a hallmark of Burkitt lymphoma. However, MYC rearrangements can also be seen in DLBCL. Staging of lymphoma relies primarily on radiographic findings and is determined by the location and extent of tumor involvement. Lymphoma is not a surgically resectable disease. Treatment primarily involves chemotherapy. Although children with mature B-cell lymphomas typically have good outcomes following treatment, they are at risk of tumor lysis syndrome due to high tumor burden. Additional therapy is required during treatment to mitigate this risk. Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The article processing fee for this article was funded by an Open Access Award given by the Society of {\textquoteleft}67, which supports the mission of the Association of Pathology Chairs to produce the next generation of outstanding investigators and educational scholars in the field of pathology. This award helps to promote the publication of high-quality original scholarship in Academic Pathology by authors at an early stage of academic development. ORCID iD Caitlin J. Alexander MD https://orcid.org/0000-0001-6946-7731 Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The article processing fee for this article was funded by an Open Access Award given by the Society of ?67, which supports the mission of the Association of Pathology Chairs to produce the next generation of outstanding investigators and educational scholars in the field of pathology. This award helps to promote the publication of high-quality original scholarship in Academic Pathology by authors at an early stage of academic development. Publisher Copyright: {\textcopyright} The Author(s) 2019.",
year = "2019",
doi = "10.1177/2374289519884733",
language = "English (US)",
volume = "6",
journal = "Academic Pathology",
issn = "2374-2895",
publisher = "SAGE Publications Ltd",
}