Edited magnetic resonance spectroscopy in the neonatal brain

Yulu Song; Peter J. Lally; Maria Yanez Lopez; Georg Oeltzschner; Mary Beth Nebel; Borjan Gagoski; Steven Kecskemeti; Steve C.N. Hui; Helge J. Zöllner; Deepika Shukla; Tomoki Arichi; Enrico De Vita; Vivek Yedavalli; Sudhin Thayyil; Daniele Fallin; Douglas C. Dean; P. Ellen Grant; Jessica L. Wisnowski; Richard A.E. Edden

doi:10.1007/s00234-021-02821-9

Edited magnetic resonance spectroscopy in the neonatal brain

Yulu Song, Peter J. Lally, Maria Yanez Lopez, Georg Oeltzschner, Mary Beth Nebel, Borjan Gagoski, Steven Kecskemeti, Steve C.N. Hui, Helge J. Zöllner, Deepika Shukla, Tomoki Arichi, Enrico De Vita, Vivek Yedavalli, Sudhin Thayyil, Daniele Fallin, Douglas C. Dean, P. Ellen Grant, Jessica L. Wisnowski, Richard A.E. Edden

Research output: Contribution to journal › Review article › peer-review

Abstract

J-difference-edited spectroscopy is a valuable approach for the detection of low-concentration metabolites with magnetic resonance spectroscopy (MRS). Currently, few edited MRS studies are performed in neonates due to suboptimal signal-to-noise ratio, relatively long acquisition times, and vulnerability to motion artifacts. Nonetheless, the technique presents an exciting opportunity in pediatric imaging research to study rapid maturational changes of neurotransmitter systems and other metabolic systems in early postnatal life. Studying these metabolic processes is vital to understanding the widespread and rapid structural and functional changes that occur in the first years of life. The overarching goal of this review is to provide an introduction to edited MRS for neonates, including the current state-of-the-art in editing methods and editable metabolites, as well as to review the current literature applying edited MRS to the neonatal brain. Existing challenges and future opportunities, including the lack of age-specific reference data, are also discussed.

Original language	English (US)
Pages (from-to)	217-232
Number of pages	16
Journal	Neuroradiology
Volume	64
Issue number	2
DOIs	https://doi.org/10.1007/s00234-021-02821-9
State	Published - Feb 2022

Keywords

Edited MRS
J-difference editing
Low-concentration metabolites
Neonatal brain
Relaxation time

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1007/s00234-021-02821-9

Cite this

Song, Y., Lally, P. J., Yanez Lopez, M., Oeltzschner, G., Nebel, M. B., Gagoski, B., Kecskemeti, S., Hui, S. C. N., Zöllner, H. J., Shukla, D., Arichi, T., De Vita, E., Yedavalli, V., Thayyil, S., Fallin, D., Dean, D. C., Grant, P. E., Wisnowski, J. L., & Edden, R. A. E. (2022). Edited magnetic resonance spectroscopy in the neonatal brain. Neuroradiology, 64(2), 217-232. https://doi.org/10.1007/s00234-021-02821-9

Song, Y, Lally, PJ, Yanez Lopez, M, Oeltzschner, G , Nebel, MB, Gagoski, B, Kecskemeti, S, Hui, SCN, Zöllner, HJ, Shukla, D, Arichi, T, De Vita, E, Yedavalli, V, Thayyil, S, Fallin, D, Dean, DC, Grant, PE, Wisnowski, JL & Edden, RAE 2022, 'Edited magnetic resonance spectroscopy in the neonatal brain', Neuroradiology, vol. 64, no. 2, pp. 217-232. https://doi.org/10.1007/s00234-021-02821-9

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abstract = "J-difference-edited spectroscopy is a valuable approach for the detection of low-concentration metabolites with magnetic resonance spectroscopy (MRS). Currently, few edited MRS studies are performed in neonates due to suboptimal signal-to-noise ratio, relatively long acquisition times, and vulnerability to motion artifacts. Nonetheless, the technique presents an exciting opportunity in pediatric imaging research to study rapid maturational changes of neurotransmitter systems and other metabolic systems in early postnatal life. Studying these metabolic processes is vital to understanding the widespread and rapid structural and functional changes that occur in the first years of life. The overarching goal of this review is to provide an introduction to edited MRS for neonates, including the current state-of-the-art in editing methods and editable metabolites, as well as to review the current literature applying edited MRS to the neonatal brain. Existing challenges and future opportunities, including the lack of age-specific reference data, are also discussed.",

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author = "Yulu Song and Lally, {Peter J.} and {Yanez Lopez}, Maria and Georg Oeltzschner and Nebel, {Mary Beth} and Borjan Gagoski and Steven Kecskemeti and Hui, {Steve C.N.} and Z{\"o}llner, {Helge J.} and Deepika Shukla and Tomoki Arichi and {De Vita}, Enrico and Vivek Yedavalli and Sudhin Thayyil and Daniele Fallin and Dean, {Douglas C.} and Grant, {P. Ellen} and Wisnowski, {Jessica L.} and Edden, {Richard A.E.}",

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doi = "10.1007/s00234-021-02821-9",

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AU - Song, Yulu

AU - Lally, Peter J.

AU - Yanez Lopez, Maria

AU - Oeltzschner, Georg

AU - Nebel, Mary Beth

AU - Gagoski, Borjan

AU - Kecskemeti, Steven

AU - Hui, Steve C.N.

AU - Zöllner, Helge J.

AU - Shukla, Deepika

AU - Arichi, Tomoki

AU - De Vita, Enrico

AU - Yedavalli, Vivek

AU - Thayyil, Sudhin

AU - Fallin, Daniele

AU - Dean, Douglas C.

AU - Grant, P. Ellen

AU - Wisnowski, Jessica L.

AU - Edden, Richard A.E.

PY - 2022/2

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N2 - J-difference-edited spectroscopy is a valuable approach for the detection of low-concentration metabolites with magnetic resonance spectroscopy (MRS). Currently, few edited MRS studies are performed in neonates due to suboptimal signal-to-noise ratio, relatively long acquisition times, and vulnerability to motion artifacts. Nonetheless, the technique presents an exciting opportunity in pediatric imaging research to study rapid maturational changes of neurotransmitter systems and other metabolic systems in early postnatal life. Studying these metabolic processes is vital to understanding the widespread and rapid structural and functional changes that occur in the first years of life. The overarching goal of this review is to provide an introduction to edited MRS for neonates, including the current state-of-the-art in editing methods and editable metabolites, as well as to review the current literature applying edited MRS to the neonatal brain. Existing challenges and future opportunities, including the lack of age-specific reference data, are also discussed.

AB - J-difference-edited spectroscopy is a valuable approach for the detection of low-concentration metabolites with magnetic resonance spectroscopy (MRS). Currently, few edited MRS studies are performed in neonates due to suboptimal signal-to-noise ratio, relatively long acquisition times, and vulnerability to motion artifacts. Nonetheless, the technique presents an exciting opportunity in pediatric imaging research to study rapid maturational changes of neurotransmitter systems and other metabolic systems in early postnatal life. Studying these metabolic processes is vital to understanding the widespread and rapid structural and functional changes that occur in the first years of life. The overarching goal of this review is to provide an introduction to edited MRS for neonates, including the current state-of-the-art in editing methods and editable metabolites, as well as to review the current literature applying edited MRS to the neonatal brain. Existing challenges and future opportunities, including the lack of age-specific reference data, are also discussed.

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Edited magnetic resonance spectroscopy in the neonatal brain

Abstract

Keywords

ASJC Scopus subject areas

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