Ectopic Cushing syndrome caused by a pancreatic neuroendocrine tumor: A case report

Shahab Shayesteh, Daniel Fadaei Fouladi, Elliot K. Fishman, Satomi Kawamoto

Research output: Contribution to journalArticlepeer-review


Cushing syndrome is a disorder that occurs when the body is exposed to a higher than normal level of the hormone cortisol. It is most commonly caused by exogenous glucocorticoids, and less commonly due to endogenous sources. Ectopic adrenocorticotropic hormone (ACTH) syndrome is one of the rare causes of endogenous Cushing syndrome engendered by oversecretion of ACTH from a tumor outside of the pituitary or adrenal glands. We present a case of a 74-year-old male with uncontrolled type 2 diabetes mellitus who was suspected of having Cushing syndrome on chest CT due to increasing mediastinal lipomatosis and enlarging bilateral adrenal glands. Cushing syndrome was confirmed based on clinical features and biochemical tests. Further investigation revealed an ACTH-producing functional neuroendocrine tumor of the pancreas causing ectopic Cushing syndrome.

Original languageEnglish (US)
Pages (from-to)1014-1017
Number of pages4
JournalRadiology Case Reports
Issue number7
StatePublished - Jul 2020


  • Adrenocorticotropin hormone
  • CT scan
  • Ectopic Cushing syndrome
  • Mediastinal lipomatosis
  • Pancreatic neuroendocrine tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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