Ebselen effects on MPTP-induced neurotoxicity

Muralikrishnan Dhanasekaran, Subramaniam Uthayathas, Senthilkumar S. Karuppagounder, Kodeeswaran Parameshwaran, Vishnu Suppiramaniam, Manuchair Ebadi, Holly M. Brown-Borg

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10-100 μM) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalBrain research
Issue number1
StatePublished - Nov 6 2006
Externally publishedYes


  • Ebselen
  • MPTP
  • Monoamine oxidase
  • Neuroprotection
  • SH-SY5Y cell

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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