Eating fast leads to insulin resistance: Findings in middle-aged Japanese men and women

Rei Otsuka; Koji Tamakoshi; Hiroshi Yatsuya; Keiko Wada; Kunihiro Matsushita; Pei OuYang; Yo Hotta; Seiko Takefuji; Hirotsugu Mitsuhashi; Kaichiro Sugiura; Satoshi Sasaki; John G. Kral; Hideaki Toyoshima

doi:10.1016/j.ypmed.2007.07.031

Eating fast leads to insulin resistance: Findings in middle-aged Japanese men and women

Rei Otsuka, Koji Tamakoshi, Hiroshi Yatsuya, Keiko Wada, Kunihiro Matsushita, Pei OuYang, Yo Hotta, Seiko Takefuji, Hirotsugu Mitsuhashi, Kaichiro Sugiura, Satoshi Sasaki, John G. Kral, Hideaki Toyoshima

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Objective: To examine relationships between speed of eating and insulin resistance. Methods: Cross-sectional study of 2704 male (mean age and BMI: 48.2 y and 23.3 kg/m²) and 761 female (46.3 y and 21.8 kg/m²) non-diabetic Japanese civil servants, 75% clerical, and 25% manual laborers, using a two-part questionnaire on life-style factors and diet history with self-assessment of categorical speed of eating and energy intake over a 1-month period. We measured BMI, blood glucose and insulin concentrations and calculated insulin resistance using the homeostasis model assessment of insulin resistance: (HOMA-IR). Results: BMI correlated with eating rate in both sexes, and with daily energy intake in men. Multiple regression analysis of log HOMA-IR by categorical speed of eating, adjusting for age, energy intake and lifestyle factors showed a statistically significant gradual increase in HOMA-IR with increases in relative eating rate in men (p < 0.001, for trend) and in women (p < 0.01). Adjusting for BMI, this positive relationship appeared only in men (p = 0.03). Conclusions: Our results suggest that eating fast is independently associated with insulin resistance in middle-aged Japanese men and women.

Original language	English (US)
Pages (from-to)	154-159
Number of pages	6
Journal	Preventive Medicine
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/j.ypmed.2007.07.031
State	Published - Feb 2008
Externally published	Yes

Keywords

Eating behavior
Eating rate
Energy intake
Insulin resistance
Life-style factors
Obesity

ASJC Scopus subject areas

Epidemiology
Public Health, Environmental and Occupational Health

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10.1016/j.ypmed.2007.07.031

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@article{5f638f6f2c77481798f3f23fd8ae4a4b,

title = "Eating fast leads to insulin resistance: Findings in middle-aged Japanese men and women",

abstract = "Objective: To examine relationships between speed of eating and insulin resistance. Methods: Cross-sectional study of 2704 male (mean age and BMI: 48.2 y and 23.3 kg/m2) and 761 female (46.3 y and 21.8 kg/m2) non-diabetic Japanese civil servants, 75% clerical, and 25% manual laborers, using a two-part questionnaire on life-style factors and diet history with self-assessment of categorical speed of eating and energy intake over a 1-month period. We measured BMI, blood glucose and insulin concentrations and calculated insulin resistance using the homeostasis model assessment of insulin resistance: (HOMA-IR). Results: BMI correlated with eating rate in both sexes, and with daily energy intake in men. Multiple regression analysis of log HOMA-IR by categorical speed of eating, adjusting for age, energy intake and lifestyle factors showed a statistically significant gradual increase in HOMA-IR with increases in relative eating rate in men (p < 0.001, for trend) and in women (p < 0.01). Adjusting for BMI, this positive relationship appeared only in men (p = 0.03). Conclusions: Our results suggest that eating fast is independently associated with insulin resistance in middle-aged Japanese men and women.",

keywords = "Eating behavior, Eating rate, Energy intake, Insulin resistance, Life-style factors, Obesity",

author = "Rei Otsuka and Koji Tamakoshi and Hiroshi Yatsuya and Keiko Wada and Kunihiro Matsushita and Pei OuYang and Yo Hotta and Seiko Takefuji and Hirotsugu Mitsuhashi and Kaichiro Sugiura and Satoshi Sasaki and Kral, {John G.} and Hideaki Toyoshima",

note = "Funding Information: This work is supported in part by grants to Hideaki Toyoshima (17390185), Koji Tamakoshi (18590594), and Hiroshi Yatsuya (17790384) from the Ministry of Education, Culture, Sports, Science and Technology and the Japan Atherosclerosis Prevention Fund (JAPF).",

year = "2008",

month = feb,

doi = "10.1016/j.ypmed.2007.07.031",

language = "English (US)",

volume = "46",

pages = "154--159",

journal = "Preventive Medicine",

issn = "0091-7435",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Eating fast leads to insulin resistance

T2 - Findings in middle-aged Japanese men and women

AU - Otsuka, Rei

AU - Tamakoshi, Koji

AU - Yatsuya, Hiroshi

AU - Wada, Keiko

AU - Matsushita, Kunihiro

AU - OuYang, Pei

AU - Hotta, Yo

AU - Takefuji, Seiko

AU - Mitsuhashi, Hirotsugu

AU - Sugiura, Kaichiro

AU - Sasaki, Satoshi

AU - Kral, John G.

AU - Toyoshima, Hideaki

N1 - Funding Information: This work is supported in part by grants to Hideaki Toyoshima (17390185), Koji Tamakoshi (18590594), and Hiroshi Yatsuya (17790384) from the Ministry of Education, Culture, Sports, Science and Technology and the Japan Atherosclerosis Prevention Fund (JAPF).

PY - 2008/2

Y1 - 2008/2

N2 - Objective: To examine relationships between speed of eating and insulin resistance. Methods: Cross-sectional study of 2704 male (mean age and BMI: 48.2 y and 23.3 kg/m2) and 761 female (46.3 y and 21.8 kg/m2) non-diabetic Japanese civil servants, 75% clerical, and 25% manual laborers, using a two-part questionnaire on life-style factors and diet history with self-assessment of categorical speed of eating and energy intake over a 1-month period. We measured BMI, blood glucose and insulin concentrations and calculated insulin resistance using the homeostasis model assessment of insulin resistance: (HOMA-IR). Results: BMI correlated with eating rate in both sexes, and with daily energy intake in men. Multiple regression analysis of log HOMA-IR by categorical speed of eating, adjusting for age, energy intake and lifestyle factors showed a statistically significant gradual increase in HOMA-IR with increases in relative eating rate in men (p < 0.001, for trend) and in women (p < 0.01). Adjusting for BMI, this positive relationship appeared only in men (p = 0.03). Conclusions: Our results suggest that eating fast is independently associated with insulin resistance in middle-aged Japanese men and women.

AB - Objective: To examine relationships between speed of eating and insulin resistance. Methods: Cross-sectional study of 2704 male (mean age and BMI: 48.2 y and 23.3 kg/m2) and 761 female (46.3 y and 21.8 kg/m2) non-diabetic Japanese civil servants, 75% clerical, and 25% manual laborers, using a two-part questionnaire on life-style factors and diet history with self-assessment of categorical speed of eating and energy intake over a 1-month period. We measured BMI, blood glucose and insulin concentrations and calculated insulin resistance using the homeostasis model assessment of insulin resistance: (HOMA-IR). Results: BMI correlated with eating rate in both sexes, and with daily energy intake in men. Multiple regression analysis of log HOMA-IR by categorical speed of eating, adjusting for age, energy intake and lifestyle factors showed a statistically significant gradual increase in HOMA-IR with increases in relative eating rate in men (p < 0.001, for trend) and in women (p < 0.01). Adjusting for BMI, this positive relationship appeared only in men (p = 0.03). Conclusions: Our results suggest that eating fast is independently associated with insulin resistance in middle-aged Japanese men and women.

KW - Eating behavior

KW - Eating rate

KW - Energy intake

KW - Insulin resistance

KW - Life-style factors

KW - Obesity

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EP - 159

JO - Preventive Medicine

JF - Preventive Medicine

IS - 2

ER -

Eating fast leads to insulin resistance: Findings in middle-aged Japanese men and women

Abstract

Keywords

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