Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1

Horacio E. Cingolani, Nestor G. Perez, Ernesto A. Aiello, Irene L. Ennis, Carolina D. Garciarena, Maria C. Villa-Abrille, Raul A. Dulce, Claudia I. Caldiz, Alejandra M. Yeves, Maria V. Correa, Mariela B. Nolly, Gladys Chiappe De Cingolani

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCXrev), which triggers cardiac hypertrophy by activation of widely recognized Ca 2+-dependent intracellular signaling pathways.

Original languageEnglish (US)
Pages (from-to)7096-7114
Number of pages19
JournalFrontiers in Bioscience
Issue number18
StatePublished - May 1 2008
Externally publishedYes


  • Angiotensin II
  • Endothelin
  • Hypertrophy
  • NHE-1
  • Reactive Oxygen Species
  • Review
  • Slow Force Response

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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