Early Marker for Alzheimer's Disease: Hippocampus T1rho (T ) Estimation

Mohammad Haris, Erin McArdle, Matthew Fenty, Anup Singh, Christos Davatzikos, John Q. Trojanowski, Elias R. Melhem, Christopher M. Clark, Arijitt Borthakur

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Purpose: To evaluate the T1rho (T ) MRI relaxation time in hippocampus in the brain of Alzheimer's disease (AD), mild cognitive impairment (MCI), and control, and to determine whether the T shows any significant difference between these cohorts. Materials and Methods: With informed consent, AD (n 49), MCI (n = 48), and age-matched control (n = 31) un- derwent T MRI on a Siemens 1.5T Scanner. T values were automatically calculated from the left and right hip- pocampus region using in-house developed software. Bon- ferroni post-hoc multiple comparisons was performed to compare the T value among the different cohorts. Results: Significantly higher T values were observed both in AD (P = 0.000) and MCI (P = 0.037) cohorts compared to control; also, the T in AD was significantly high over (P = 0.032) MCI. Hippocampus T was 13% greater in the AD patients than control, while in MCI it was 7% greater than control. Hippocampus T in AD patients was 6% greater than MCI. Conclusion: Higher hippocampus T values in the AD pa- tients might be associated with the increased plaques bur- den. A follow-up study would help to determine the efficacy of T values as a predictor of developing AD in the control and MCI individuals.

Original languageEnglish (US)
Pages (from-to)1008-1012
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Issue number5
StatePublished - May 2009
Externally publishedYes


  • Alzheimer's disease
  • Hippocampus
  • MRI
  • T1rho

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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