TY - JOUR
T1 - Early in vivo experience with the pediatric Jarvik 2000 heart
AU - Kilic, Ahmet
AU - Nolan, Timothy D.C.
AU - Li, Tieluo
AU - Yankey, G. Kwame
AU - Prastein, Deyanira J.
AU - Cheng, Guangming
AU - Jarvik, Robert K.
AU - Wu, Zhongjun J.
AU - Griffith, Bartley P.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/5
Y1 - 2007/5
N2 - The need for smaller, more efficient ventricular assist devices that can be used in a more chronic setting have led to exploration of mechanical circulatory support in the pediatric population. The pediatric Jarvik 2000 heart (child size), under development, was implanted in six juvenile sheep and studied for both acute fit and chronic performance evaluation. Daily hemodynamic measurements of cardiac output and pump output at varying pump speeds were taken. In addition, plasma free hemoglobin, lactic acid dehydrogenase, and platelet activation from blood samples were determined at baseline, after implantation, and twice a week thereafter. The measured flow through the outflow graft at increasing speeds from 10,000 rpm to 14,000 rpm with an increment of 1,000 rpm were 1.47 ± 0.43, 1.89 ± 0.52, 2.36 ± 0.61, 2.80 ± 0.73, and 3.11 ± 0.86 (L/min). The baseline plasma free hemoglobin was 11.95 ± 4.76 (mg/dL), with subsequent mean values being <30 mg/dL at postimplantation and weekly postimplantation measurements. Both lactic acid dehydrogenase and platelet activation showed an acute increase within the first week after implantation with subsequent return to baseline by 2 weeks after surgery. Our initial animal in vivo experience with the pediatric Jarvik 2000 heart shows that a small axial flow pump can provide partial to nearly complete circulatory support with minimal adverse effects on blood components.
AB - The need for smaller, more efficient ventricular assist devices that can be used in a more chronic setting have led to exploration of mechanical circulatory support in the pediatric population. The pediatric Jarvik 2000 heart (child size), under development, was implanted in six juvenile sheep and studied for both acute fit and chronic performance evaluation. Daily hemodynamic measurements of cardiac output and pump output at varying pump speeds were taken. In addition, plasma free hemoglobin, lactic acid dehydrogenase, and platelet activation from blood samples were determined at baseline, after implantation, and twice a week thereafter. The measured flow through the outflow graft at increasing speeds from 10,000 rpm to 14,000 rpm with an increment of 1,000 rpm were 1.47 ± 0.43, 1.89 ± 0.52, 2.36 ± 0.61, 2.80 ± 0.73, and 3.11 ± 0.86 (L/min). The baseline plasma free hemoglobin was 11.95 ± 4.76 (mg/dL), with subsequent mean values being <30 mg/dL at postimplantation and weekly postimplantation measurements. Both lactic acid dehydrogenase and platelet activation showed an acute increase within the first week after implantation with subsequent return to baseline by 2 weeks after surgery. Our initial animal in vivo experience with the pediatric Jarvik 2000 heart shows that a small axial flow pump can provide partial to nearly complete circulatory support with minimal adverse effects on blood components.
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U2 - 10.1097/MAT.0b013e318038fc1f
DO - 10.1097/MAT.0b013e318038fc1f
M3 - Article
C2 - 17515732
AN - SCOPUS:34249099649
SN - 1058-2916
VL - 53
SP - 374
EP - 378
JO - ASAIO Journal
JF - ASAIO Journal
IS - 3
ER -