Early Detection of Retinal Involvement In Diabetes By Vitreous Fluorophotometry

José G. Cunha-Vaz; Morton F. Goldberg; Charles Vygantas; James Noth

doi:10.1016/S0161-6420(79)35516-6

Early Detection of Retinal Involvement In Diabetes By Vitreous Fluorophotometry

José G. Cunha-Vaz, Morton F. Goldberg, Charles Vygantas, James Noth

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Vitreous fluorophotometry is a new quantitative method for evaluation of the blood-retinal barrier (BRB). The application of this method to a series of diabetic patients with apparently normal fundi revealed the presence of a significant breakdown of the BRB in the early stages of retinal involvement in diabetes. This alteration of the BRB appears to be the earliest clinically detectable change to occur in the retina in diabetes. Higher vitreous fluorophotometry values, indicating a more marked breakdown of the BRB, occurred in patients who were under worse metabolic control. Higher vitreous fluorophotometry values were also associated with the development of visible retinal lesions.

Original language	English (US)
Pages (from-to)	264-275
Number of pages	12
Journal	Ophthalmology
Volume	86
Issue number	2
DOIs	https://doi.org/10.1016/S0161-6420(79)35516-6
State	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0161-6420(79)35516-6

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title = "Early Detection of Retinal Involvement In Diabetes By Vitreous Fluorophotometry",

abstract = "Vitreous fluorophotometry is a new quantitative method for evaluation of the blood-retinal barrier (BRB). The application of this method to a series of diabetic patients with apparently normal fundi revealed the presence of a significant breakdown of the BRB in the early stages of retinal involvement in diabetes. This alteration of the BRB appears to be the earliest clinically detectable change to occur in the retina in diabetes. Higher vitreous fluorophotometry values, indicating a more marked breakdown of the BRB, occurred in patients who were under worse metabolic control. Higher vitreous fluorophotometry values were also associated with the development of visible retinal lesions.",

author = "Cunha-Vaz, {Jos{\'e} G.} and Goldberg, {Morton F.} and Charles Vygantas and James Noth",

note = "Funding Information: This study was supported by grants from Kroc Foundation, Santa Inez, USA, and Instituto Nacional de Investigacao Cientifica, Portugal.",

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T1 - Early Detection of Retinal Involvement In Diabetes By Vitreous Fluorophotometry

AU - Cunha-Vaz, José G.

AU - Goldberg, Morton F.

AU - Vygantas, Charles

AU - Noth, James

N1 - Funding Information: This study was supported by grants from Kroc Foundation, Santa Inez, USA, and Instituto Nacional de Investigacao Cientifica, Portugal.

PY - 1979

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N2 - Vitreous fluorophotometry is a new quantitative method for evaluation of the blood-retinal barrier (BRB). The application of this method to a series of diabetic patients with apparently normal fundi revealed the presence of a significant breakdown of the BRB in the early stages of retinal involvement in diabetes. This alteration of the BRB appears to be the earliest clinically detectable change to occur in the retina in diabetes. Higher vitreous fluorophotometry values, indicating a more marked breakdown of the BRB, occurred in patients who were under worse metabolic control. Higher vitreous fluorophotometry values were also associated with the development of visible retinal lesions.

AB - Vitreous fluorophotometry is a new quantitative method for evaluation of the blood-retinal barrier (BRB). The application of this method to a series of diabetic patients with apparently normal fundi revealed the presence of a significant breakdown of the BRB in the early stages of retinal involvement in diabetes. This alteration of the BRB appears to be the earliest clinically detectable change to occur in the retina in diabetes. Higher vitreous fluorophotometry values, indicating a more marked breakdown of the BRB, occurred in patients who were under worse metabolic control. Higher vitreous fluorophotometry values were also associated with the development of visible retinal lesions.

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Early Detection of Retinal Involvement In Diabetes By Vitreous Fluorophotometry

Abstract

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