Early complement component depletion and mixed cryoglobulinemia in a “healthy” family

John R. Waterman; Jerry A. Winkelstein; Ronald N. Berzofsky; Susan H. Hsu; Wilma B. Bias; Frank C. Arnett

doi:10.1002/art.1780220909

Early complement component depletion and mixed cryoglobulinemia in a “healthy” family

John R. Waterman, Jerry A. Winkelstein, Ronald N. Berzofsky, Susan H. Hsu, Wilma B. Bias, Frank C. Arnett

Research output: Contribution to journal › Article › peer-review

Abstract

A family containing two apparently healthy brothers with profound early complement component depletion (C1, C4, C2) and mixed IgG‐IgM polyclonal cryoglobulins was studied. The cryoglobulins possessed rheumatoid factor activity and depleted early complement components in normal human serum. Circulating immune complexes could not be detected by utilizing standard methods. The phenomenon was not HLA‐linked. This study demonstrates the familial occurrence of a chronic hypocomplementemic state associated with cryoglobulinemia in clinically normal subjects.

Original language	English (US)
Pages (from-to)	1006-1012
Number of pages	7
Journal	Arthritis & Rheumatism
Volume	22
Issue number	9
DOIs	https://doi.org/10.1002/art.1780220909
State	Published - Sep 1979
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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10.1002/art.1780220909

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AU - Arnett, Frank C.

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Early complement component depletion and mixed cryoglobulinemia in a “healthy” family

Abstract

ASJC Scopus subject areas

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