Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection

Jan R. Bautista, Gary J. Schwartz, Juan Carlos De La Torre, Timothy H. Moran, Kathryn M. Carbone

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a normal aversion for quinine, but an exaggerated preference for saline. At 1 and 4 months of age, PTI-NB rats were significantly more active than normal rats, although only 1-month-old PTI-NB rats had increased daytime activity. Thus, even in the absence of encephalitis, BDV infection of the PTI-NB rat is associated with a number of physiological and behavioral abnormalities.

Original languageEnglish (US)
Pages (from-to)31-40
Number of pages10
JournalBrain Research Bulletin
Issue number1
StatePublished - 1994


  • Activity
  • Behavior
  • Borna
  • Brain
  • Development
  • Growth
  • Rat
  • Taste
  • Virus

ASJC Scopus subject areas

  • General Neuroscience


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