Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Stem cells are characterized by the capacity for both self-renewal and generation of all other cell types (pluripotency) or differentiated cells within a particular lineage (multipotency). Stem cells are often localized to hypoxic niches within tissues and hypoxia inducible factors (HIFs) play key roles in the maintenance of pluripotent and multipotent stem cells, as well as cancer stem cells, which are also known as tumor-initiating cells. HIF inhibitors target cancer stem cells and improve the responses to angiogenesis inhibitors and cytotoxic chemotherapy in mouse models of breast cancer.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalMolecular Aspects of Medicine
Volume47-48
DOIs
StatePublished - Feb 1 2016

Keywords

  • Breast cancer stem cells
  • Embryonic stem cells
  • Glioma stem cells
  • Hematopoietic stem cells
  • Induced pluripotent stem cells
  • Leukemia stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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