Abstract
Purpose Recently, natural d-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using d-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown. Methods Mice were inoculated orthotopically with human U87-EGFRvIII glioma cells. Time-resolved glucose signal changes were detected using chemical exchange saturation transfer (glucoCEST) MRI. Dynamic glucose enhanced (DGE) MRI was used to measure tissue response to an intravenous bolus of d-glucose. Results DGE images of mouse brains bearing human glioma showed two times higher and persistent changes in tumor compared with contralateral brain. Area-under-curve (AUC) analysis of DGE delineated blood vessels and tumor and had contrast comparable to the AUC determined using dynamic contrast enhanced (DCE) MRI with GdDTPA, both showing a significantly higher AUC in tumor than in brain (P < 0.005). Both CEST and relaxation effects contribute to the signal change. Conclusion DGE MRI is a feasible technique for studying brain tumor enhancement reflecting differences in tumor blood volume and permeability with respect to normal brain. We expect DGE will provide a low-risk and less expensive alternative to DCE MRI for imaging cancer in vulnerable populations, such as children and patients with renal impairment. Magn Reson Med 74:1556-1563, 2015.
Original language | English (US) |
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Pages (from-to) | 1556-1563 |
Number of pages | 8 |
Journal | Magnetic resonance in medicine |
Volume | 74 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1 2015 |
Keywords
- D-glucose
- brain cancer
- chemical exchange saturation transfer (CEST)
- dynamic glucose enhanced MRI
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging