TY - JOUR
T1 - Dynamic functional connectivity in the static connectome of Caenorhabditis elegans
AU - Flavell, Steven W.
AU - Gordus, Andrew
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2022/4
Y1 - 2022/4
N2 - A hallmark of adaptive behavior is the ability to flexibly respond to sensory cues. To understand how neural circuits implement this flexibility, it is critical to resolve how a static anatomical connectome can be modulated such that functional connectivity in the network can be dynamically regulated. Here, we review recent work in the roundworm Caenorhabditis elegans on this topic. EM studies have mapped anatomical connectomes of many C. elegans animals, highlighting the level of stereotypy in the anatomical network. Brain-wide calcium imaging and studies of specified neural circuits have uncovered striking flexibility in the functional coupling of neurons. The coupling between neurons is controlled by neuromodulators that act over long timescales. This gives rise to persistent behavioral states that animals switch between, allowing them to generate adaptive behavioral responses across environmental conditions. Thus, the dynamic coupling of neurons enables multiple behavioral states to be encoded in a physically stereotyped connectome.
AB - A hallmark of adaptive behavior is the ability to flexibly respond to sensory cues. To understand how neural circuits implement this flexibility, it is critical to resolve how a static anatomical connectome can be modulated such that functional connectivity in the network can be dynamically regulated. Here, we review recent work in the roundworm Caenorhabditis elegans on this topic. EM studies have mapped anatomical connectomes of many C. elegans animals, highlighting the level of stereotypy in the anatomical network. Brain-wide calcium imaging and studies of specified neural circuits have uncovered striking flexibility in the functional coupling of neurons. The coupling between neurons is controlled by neuromodulators that act over long timescales. This gives rise to persistent behavioral states that animals switch between, allowing them to generate adaptive behavioral responses across environmental conditions. Thus, the dynamic coupling of neurons enables multiple behavioral states to be encoded in a physically stereotyped connectome.
UR - http://www.scopus.com/inward/record.url?scp=85124646792&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85124646792&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2021.12.002
DO - 10.1016/j.conb.2021.12.002
M3 - Review article
C2 - 35183877
AN - SCOPUS:85124646792
SN - 0959-4388
VL - 73
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
M1 - 102515
ER -