TY - JOUR
T1 - Duration of the enhanced activity of the microsomal ethanol-oxidizing enzyme system and rate of ethanol degradation in ethanol-fed rats after withdrawal
AU - Mezey, Esteban
N1 - Funding Information:
work was supported
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1972/1/15
Y1 - 1972/1/15
N2 - The activities of ethanol-oxidizing enzymes, drug-metabolizing enzymes and rates of ethanol disappearance from the blood were determined in rats after 14 days of ethanol feeding and after withdrawal. The microsomal ethanol-oxidizing system, cytochrome P-450, aniline hydroxylase and the rates of ethanol disappearance from the blood were enhanced by ethanol feeding. Alcohol dehydrogenase remained unchanged. After withdrawal, the rates ofethanol disappearance from the blood returned to control values in 2 days, while the activities of the microsomal enzymes did not fall to control values until 7 days. The lack of parallelism in the fall of the rates ofethanol disappearance from the blood and the microsomal enzymes suggests that factors other than the enhanced activity of the microsomal ethanol-oxidizing enzyme system are responsible for the increases in rates of ethanol degradation after ethanol feeding.
AB - The activities of ethanol-oxidizing enzymes, drug-metabolizing enzymes and rates of ethanol disappearance from the blood were determined in rats after 14 days of ethanol feeding and after withdrawal. The microsomal ethanol-oxidizing system, cytochrome P-450, aniline hydroxylase and the rates of ethanol disappearance from the blood were enhanced by ethanol feeding. Alcohol dehydrogenase remained unchanged. After withdrawal, the rates ofethanol disappearance from the blood returned to control values in 2 days, while the activities of the microsomal enzymes did not fall to control values until 7 days. The lack of parallelism in the fall of the rates ofethanol disappearance from the blood and the microsomal enzymes suggests that factors other than the enhanced activity of the microsomal ethanol-oxidizing enzyme system are responsible for the increases in rates of ethanol degradation after ethanol feeding.
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U2 - 10.1016/0006-2952(72)90263-8
DO - 10.1016/0006-2952(72)90263-8
M3 - Article
C2 - 4674908
AN - SCOPUS:0015506764
SN - 0006-2952
VL - 21
SP - 137
EP - 142
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 2
ER -