Duration of Preventive Antibiotic Administration for Open Extremity Fractures

E. Patchen Dellinger, Ellis S. Caplan, Lance D. Weaver, Margaret J. Wertz, Beth M. Droppert, Nancy Hoyt, Robert Brumback, Andrew Burgess, Attila Poka, Stephen K. Benirschke, E. Stan Lennard, Mary Ann Lou

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


The necessary duration of antibiotic administration after open fracture has not been established. In a double-blind prospective trial we randomized 248 patients with open fractures to receive one or five days of cefonicid sodium therapy or five days of cefamandole nafate therapy as part of the initial treatment. Rates of fracture-associated infections in the three groups were ten (13%) of 79, ten (12%) of 85, and 11 (13%) of 84, respectively. The 95% confidence limit for the difference in infection rates between the one-day group and the combined five-day groups was 0% to 8.3%. The actual difference was 0.2%. A brief course of antibiotic administration is not inferior to a prolonged course of antibiotics for prevention of postoperative fracture-site infections.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalArchives of surgery
Issue number3
StatePublished - Mar 1988
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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