Duration of Preventive Antibiotic Administration for Open Extremity Fractures

E. Patchen Dellinger; Ellis S. Caplan; Lance D. Weaver; Margaret J. Wertz; Beth M. Droppert; Nancy Hoyt; Robert Brumback; Andrew Burgess; Attila Poka; Stephen K. Benirschke; E. Stan Lennard; Mary Ann Lou

doi:10.1001/archsurg.1988.01400270067010

Duration of Preventive Antibiotic Administration for Open Extremity Fractures

E. Patchen Dellinger, Ellis S. Caplan, Lance D. Weaver, Margaret J. Wertz, Beth M. Droppert, Nancy Hoyt, Robert Brumback, Andrew Burgess, Attila Poka, Stephen K. Benirschke, E. Stan Lennard, Mary Ann Lou

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

The necessary duration of antibiotic administration after open fracture has not been established. In a double-blind prospective trial we randomized 248 patients with open fractures to receive one or five days of cefonicid sodium therapy or five days of cefamandole nafate therapy as part of the initial treatment. Rates of fracture-associated infections in the three groups were ten (13%) of 79, ten (12%) of 85, and 11 (13%) of 84, respectively. The 95% confidence limit for the difference in infection rates between the one-day group and the combined five-day groups was 0% to 8.3%. The actual difference was 0.2%. A brief course of antibiotic administration is not inferior to a prolonged course of antibiotics for prevention of postoperative fracture-site infections.

Original language	English (US)
Pages (from-to)	333-339
Number of pages	7
Journal	Archives of surgery
Volume	123
Issue number	3
DOIs	https://doi.org/10.1001/archsurg.1988.01400270067010
State	Published - Mar 1988
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1001/archsurg.1988.01400270067010

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title = "Duration of Preventive Antibiotic Administration for Open Extremity Fractures",

abstract = "The necessary duration of antibiotic administration after open fracture has not been established. In a double-blind prospective trial we randomized 248 patients with open fractures to receive one or five days of cefonicid sodium therapy or five days of cefamandole nafate therapy as part of the initial treatment. Rates of fracture-associated infections in the three groups were ten (13%) of 79, ten (12%) of 85, and 11 (13%) of 84, respectively. The 95% confidence limit for the difference in infection rates between the one-day group and the combined five-day groups was 0% to 8.3%. The actual difference was 0.2%. A brief course of antibiotic administration is not inferior to a prolonged course of antibiotics for prevention of postoperative fracture-site infections.",

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AU - Dellinger, E. Patchen

AU - Caplan, Ellis S.

AU - Weaver, Lance D.

AU - Wertz, Margaret J.

AU - Droppert, Beth M.

AU - Hoyt, Nancy

AU - Brumback, Robert

AU - Burgess, Andrew

AU - Poka, Attila

AU - Benirschke, Stephen K.

AU - Lennard, E. Stan

AU - Lou, Mary Ann

PY - 1988/3

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AB - The necessary duration of antibiotic administration after open fracture has not been established. In a double-blind prospective trial we randomized 248 patients with open fractures to receive one or five days of cefonicid sodium therapy or five days of cefamandole nafate therapy as part of the initial treatment. Rates of fracture-associated infections in the three groups were ten (13%) of 79, ten (12%) of 85, and 11 (13%) of 84, respectively. The 95% confidence limit for the difference in infection rates between the one-day group and the combined five-day groups was 0% to 8.3%. The actual difference was 0.2%. A brief course of antibiotic administration is not inferior to a prolonged course of antibiotics for prevention of postoperative fracture-site infections.

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Duration of Preventive Antibiotic Administration for Open Extremity Fractures

Abstract

ASJC Scopus subject areas

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